Sony Corporation

Sony Electronics Inc

Sony Computer Entertainment Inc.

International Business Machines Corporation

Toshiba America Electronic Components, Inc.

Sony Group Corporation

Yosuke Muraki

Fumitaka Otsuka

Akiko Tsuji

Takashi Miyata

Yasunobu Kato

Makoto Aikawa

Iwao Takiguchi

Tetsuji Tamura

Sang Hoo Dhong

Kirk David Peterson

David William Boerstler

Jieming Qi

Eskinder Hailu

Koji Inoue

Gakuji Hashimoto

Toshiyuki Hiroi

Robert Walter Berry, Jr

Byron Lee Krauter

Stephen Douglas Weitzel

Kazuhiko Miki

Masaya Kakuta

Gilles Gervais

Atsuo Fujimaki

Kouhei Hatamoto

Masashi Saitoh

Shigemi Sakamoto

Provided are a microparticle sorting device, and a method and a program for sorting microparticles capable of stabilizing sorting performance over a prolonged period of time. The microparticle sorting device includes an imaging element and a controller. The imaging element obtains an image of fluid and fluid droplets at a position where the fluid discharged from an orifice which generates a fluid stream is converted into the fluid droplets. The controller controls driving voltage of an oscillation element which gives oscillation to the orifice and/or controls a position of the imaging element based on a state of the fluid in the image and/or a state of a satellite fluid droplet. The satellite fluid droplet does not include microparticles and exists between the position, where the fluid is converted into the fluid droplets, and a fluid droplet, among fluid droplets including the microparticles, which is closest to the position where the fluid is converted into the fluid droplets.

Microparticle sorting device, and method and program for sorting microparticles

A flow cytometer includes apparatus for evaluating a trajectory of an ejected stream that carries micro-particles. The stream may be ejected from a micro-orifice of a micro-fluidic chip. The apparatus includes an imaging device and at least one processor configured to evaluate a trajectory of the ejected stream in at least two directions, e.g., a focusing direction and a direction transverse to the focusing direction. Based upon a detected trajectory, the system may execute an alarm function if the trajectory indicates an abnormal condition, or may move sample collection containers to accommodate for measured deviations in the trajectory of the ejected stream.

Micro-particle sorting apparatus and method of determining a trajectory of an ejected stream carrying micro-particles

A microparticle sorting apparatus includes a detection unit which detects microparticles flowing through a flow path; an imaging device which images a droplet containing the microparticles which is discharged from an orifice provided on an edge portion of the flow path; a charge unit which applies a charge to the droplets; and a control unit which determines a delay time as from a time that the microparticles are detected by the detection unit to the time at which a number of bright spots in a standard region, which is set beforehand, of image information imaged by the imaging device reaches the maximum, making it possible for the charge unit to apply a charge to the microparticles once the delay time has lapsed after the microparticles are detected by the detection unit.

Microparticle sorting apparatus and delay time determination method

To provide a microchip-type optical measuring apparatus which is able to automatically perform position adjustment of a microchip with respect to an optical axis of laser with high accuracy. A microchip-type optical measuring apparatus includes an irradiation detection unit which detects light generated by irradiating a microchip with laser, a position adjustment unit which changes a relative position of the microchip with respect to the irradiation detection unit, and a control unit which outputs a movement signal for a position in which an integrated value or an average value of a detected intensity of the light in a preset region becomes high to the position adjustment unit.

Microchip-type optical measuring apparatus and optical position adjusting method thereof

Provided are a fine particle analyzing apparatus, a fine particle analyzing method, a program, and a fine particle analyzing system, which are capable of easily separating a plurality of types of spectral data on fluorescence emitted from a fine particle. A data extracting unit included in the fine particle analyzing apparatus selectively extracts spectral data, which contain predetermined information, from spectral data on fluorescence emitted from a fine particle. The data extracting unit selectively extracts spectral data indicating the maximum intensity in a wavelength area set beforehand from one or a plurality of types of spectral data indicating intensity of fluorescence emitted from the fine particle for each of a plurality of wavelengths.

Fine particle analyzing apparatus, fine particle analyzing method, program, and fine particle analyzing system

Provided is a microparticle measurement device that can deliver a liquid used in the analysis of microparticles in a stable manner. The microparticle measurement device includes a plurality of first tank units to which a liquid is supplied from the outside, and which are respectively connected in parallel, and a bulb unit that is connected to the plurality of first tank units, and which switches to a state in which it is possible to deliver the liquid to a flow channel through which microparticles flow. According to this microparticle measurement device, in addition to performing liquid delivery from a portion of the plurality of first tank units, in which the replenishment of liquid has been completed, to a flow channel, it is possible to supply liquid from the outside to the plurality of first tank units other than the plurality of first tank units that are delivering liquid.

Microparticle measurement device and liquid delivery method in microparticle measurement device

[Object] To provide a particle sorting apparatus, a particle sorting method, and a program that are capable of efficiently sorting particles even when sizes of particles to be sorted are not uniform. [Solving Means] A particle sorting apparatus includes a charge section that imparts charges to at least a part of droplets discharged from an orifice from which a fluid stream is generated, and a charge control section that adjusts a charge amount to be imparted to the droplets by the charge section. Further, the charge control section is structured to adjust the charge amount according to sizes of particles included in the droplets.

Particle sorting apparatus, particle sorting method, and program

There is provided a microparticle sorting device that automatically optimizes a fluid stream. There is provided a microparticle sorting device that includes a voltage supply unit that supplies a driving voltage to a vibratory element that applies vibration to an orifice that produces a fluid stream, a charge unit that imparts charge to at least some droplets ejected from the orifice, deflecting plates, arranged opposing each other with the fluid stream S therebetween, that vary a travel direction of the droplets, and a first image sensor that acquires an image of the droplets passing between the deflecting plates. The microparticle sorting device is equipped with a controller that detects the droplets in the image, sets a standard band corresponding to a width of the droplets before imparting the charge, and controls the driving voltage of the voltage supply unit so as to further decrease a quantity of the droplets detected in areas within a designated number of pixels from the standard band from among the droplets after imparting the charge.

Microparticle sorting device and method of optimizing fluid stream therein

A particle fractionating apparatus is described that can sort droplets containing particles in a first mode of operation, and distribute droplets that do not contain particles to a plurality of locations in a second mode of operation. The modes of operation are selectable by a user. Droplets may be emitted from a microchip of the particle fractionating apparatus.

Particle fractionation apparatus, particle fractionation method and particle fractionation program

Provided is a microparticle measurement device that can deliver a liquid that is used in the analysis of microparticles in a stable manner. The microparticle measurement device includes a plurality of first tank units to which a liquid is supplied from the outside, and which are respectively arranged in parallel, and a bulb unit that is connected to the plurality of first tank units, and which switches to a state in which it is possible to deliver the liquid to a flow channel through which microparticles flow. According to this microparticle measurement device, in addition to performing liquid delivery from a portion of first tank units, in which the replenishment of liquid has been completed, to a flow channel, it is possible to supply liquid from the outside to first tank units other than the first tank units that are delivering liquid.

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Tokyo, Japan

Yosuke Muraki