Dominion Pharmakine S.l

Universidad Del País Vasco

Universidad Del País Vasco/euskal Herriko Unibertsitatea

Ikerchem, S.l.

Yosu Ion Vara Salazar

Aizpea Zubia Olascoaga

Eneko Aldaba Arévalo

Fernando Vidal Vanaclocha

Miren Lorea Mendoza Arteche

Natalia Gallot Escobal

Fernando Pedro Cossio Mora

Fernando Pedro Cossio

Silvia Vivanco Amato

Eneko Aldaba Arevalo

Clarisa Salado Pogonza

Miren Sorne Solaun Aguirre

Jose Javier Lopez Pestana

Eider San Sebastian Larzabal

Maria Del Masdeu Margalef

Dorleta Otaegui Ansa

This invention is related to new nitrogenated trans-stilbene compounds, more specifically, imine, pyrrole and indole derivatives, with procedures for the preparation and use thereof as pharmaceutical compositions for the treatment and/or chemoprevention of those mammalian diseases such as cancer, fibrosclerosis and acute/chronic inflammation, graft-versus-host reaction, ischemic-reperfusion tissue injury in stroke and heart attack, neurodegeneration, and during organ transplantation, whose pathogenic and pathophysiological mechanisms depend on or are significantly contributed by undesirable oxidative stress, angiogenic and proliferative responses.

Nitrogenated trans-stilbene analogs, method for the obtention and medical applications thereof

The invention relates to the treatment of disorders or diseases mediated by LFA-1/ICAM-1 molecular interaction. This is based on the use of novel chemical compounds capable of inhibiting said interaction, and more particularly, to pharmaceutical compositions containing these compounds.

Inhibitors of the LFA-1/ICAM-1 interaction and uses thereof

Growing community of inventors

Leioa, Spain

Yosu Ion Vara Salazar