Toray Industries, Inc.

Shiga University of Medical Science

Yoshiyuki Ueno

Hiroyuki Sugaya

Akihiro Hayashi

Naotoshi Tomita

Suguru Ushiro

Hiroaki Fujieda

Masaki Fujita

Kazumi Tanaka

Junichi Kasuya

Kazuhiro Tanahashi

Hiroshi Takahashi

Hirokazu Sakaguchi

Masaaki Shimagaki

Masahiro Osabe

Tatsuya Kishikawa

Ryo Matsunaga

Yuji Ueda

Kaoru Shimada

Masato Masuda

Kazuo Teramoto

Joji Funakoshi

Kazuyuki Hashimoto

Yasunori Kanemori

Hiroyuki Terasaka

Tomonori Kawakami

Kaori Akaike

Hirofumi Yamanaka

Kazumasa Ogasawara

Shigenori Tanaka

Tomoaki Osuka

Yoshihiro Eika

Miho Araki

Aishan Han

Tomoya Hayashi

Shiro Nosaka

Ryo Koganemaru

Takeshi Baba

Masayuki Yamada

Sari Iwakawa

An object of the present invention is to provide a purification column which is a small purification column in which a volume of a liquid to be treated is reduced in order to reduce the amount of blood to be taken out and which realizes a low pressure loss and has high adsorption performance. The present invention provides a fiber bundle including a plurality of porous fibers that satisfies the following requirements (A) to (E):

Fiber bundle, method for producing same, and purification column

Disclosed is a porous hollow fiber membrane containing a polysulfone-based polymer as a main component, which has an asymmetric structure in which the inner surface side is dense and the outer surface side is coarse, wherein an average of a minor axis diameter of pores of an inner surface is 20 nm or more and 40 nm or less, an open porosity of the inner surface is 10% or more and 30% or less, and a polymer including a monocarboxylic acid vinyl ester unit is supported on at least one of the outer surface and the inner surface. The present invention provides a hollow fiber membrane which has excellent removing performance of substances to be separated such as viruses, and can be used as a separation membrane having high permeability even in a treatment under low pressure.

Porous hollow fiber membrane

An objective of the present disclosure is to provide an adsorption material that has a carrier material with retained physical strength, and efficiently adsorbs an immunosuppressive protein. The present disclosure provides an adsorption material for immunosuppressive protein. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae is bound. A total content of amino groups on the water-insoluble carrier is more than 0 &#x3bc;mol and 2500 &#x3bc;mol or less per 1 g, and a content of primary amino groups on the water-insoluble carrier is 450 &#x3bc;mol or less per 1 g.

Immunosuppressive protein adsorption material and adsorption column

A solid fiber is described, where the solid fiber is characterized by (a) a modification degree Do/Di, in a cross section of the solid fiber of 1.20 to 8.50 where the inscribed circle diameter is denoted by Di and the circumscribed circle diameter is denoted by Do; and (b) a porous specific surface area of not less than 30 m/g.

Porous fiber, adsorbent material, and purification column

An object of the present invention is to provide a ligand-immobilized sea-island composite fiber in which generation of fine particles due to peeling of a sea component from an island component and generation of fine particles due to destruction of a fragile sea component are both suppressed. The present invention provides a sea-island composite fiber comprising a sea component and island components, in which a value (L/S) obtained by dividing the average total length (L) of the perimeter of all island components in a cross section perpendicular to the fiber axis by the average cross-sectional area (S) of the cross section is from 1.0 to 50.0 &#x3bc;m, a distance from the surface to the outermost island component is 1.9 &#x3bc;m or less, and an amino group-containing compound is covalently bonded to a polymer constituting the sea component at a charge density of 0.1 &#x3bc;mol or more and less than 500 &#x3bc;mol per 1 gram dry weight.

Sea-island composite fiber, carrier for adsorption, and medical column provided with carrier for adsorption

The present invention provides: a porous fiber that exhibits both improved adsorption capacity, and suppressed exposure and detachment of particulates; an adsorption column filled with said porous fiber; and a blood purification system in which an adsorption column is connected to a water removal column. The porous fiber according to the present invention has a three-dimensional pore structure formed by a solid fiber, and satisfies all of the following conditions. (1) The porous fiber has particulates having a diameter of not more than 200 &#x3bc;m, and the percentage of area occupied by said particulates having a diameter of not more than 200 &#x3bc;m in a horizontal cross section of the three-dimensional pore structure is at least 3.0%. (2) The porous fiber does not contain said particulates having a diameter of not more than 200 &#x3bc;m in the region within 1.0 &#x3bc;m in the depth direction from the outermost surface.

Porous fiber and adsorption column

A copolymer is capable of being immobilized on a base material while maintaining a high antithrombotic property persistently without having to introduce heparin or an anticoagulant drug to the surface thereof. The copolymer includes monomer unit A, monomer unit B, and monomer unit C, wherein monomer unit C has a mole fraction of 0.5-40% with respect to the total amount of all constituent monomer units.

Copolymer and medical material containing the same

Disclosed is a hollow fiber membrane module including a case and a hollow fiber membrane built in the case, wherein the hollow fiber membrane contains a polysulfone-based polymer and a hydrophilic polymer, and satisfies the following (A) and (B), and an amount of an eluted substance contained in a liquid obtained by circulating ultrapure water heated at 37&#xb0; C. through a passage of an inner surface side of the hollow fiber membrane for 4 hours at 200 mL/min is 1.0 mg/mor less: (A) an insoluble component accounts for less than 3% by mass of the total mass of the hollow fiber membrane when the hollow fiber membrane is dissolved in N,N-dimethylacetamide; and (B) a flexible layer exists on a surface of a functional layer in a wet state and the flexible layer has a thickness of 7 nm or more. The present invention provides a hollow fiber membrane module including a hollow fiber membrane containing a polysulfone-based polymer and a hydrophilic polymer built therein, which elutes little eluted substance and exhibits high biocompatibility, while change in performance due to crosslinking of the hydrophilic polymer is suppressed.

Hollow fiber membrane module and manufacturing method thereof

A biological component adhesion-suppressing material includes a substrate provided with a functional layer having, fixed on a surface thereof that comes into contact with a biological component, a polymer including a saturated aliphatic monocarboxylic acid vinyl ester unit, wherein: when compositional analysis is performed on the surface of the functional layer using a TOF-SIMS device, the number of carbon atoms in an aliphatic chain representing an ion signal detected for saturated aliphatic carboxylic acid is 2-20; and an XPS measurement taken of the surface of the functional layer shows a peak derived from an ester group.

Biological component adhesion-suppressing material

A medical material is capable of suppressing adhesion of platelets and proteins even when in contact with biological components such as blood for an extended period of time. The medical material is a copolymer including hydrophobic units and hydrophilic units in which the hydrophobic units have a C2-20 terminal alkyl group in a side chain, the static contact angle of water in the copolymer is at least 30&#xb0; and less than 70&#xb0;, and the glass transition temperature of the copolymer exists at only one point in the range from 45&#xb0; C. to less than 90&#xb0; C.

Medical material, medical separation membrane, and blood purifier

A copolymer has blood compatibility and antithrombotic properties of greatly suppressing protein adhesion to be usable even when in contact with a biological component such as blood for a long period of time, and a medical device uses the copolymer. The copolymer is characterized by including a hydrophilic unit and a hydrophobic unit, wherein the hydrophobic unit contains at least one type of a carboxylic acid vinyl unit, and the number of carbon atoms at the terminal of a side chain of the carboxylic acid vinyl unit is 2-7.

Copolymer and medical device, separation membrane module for medical use, and blood purifier including the same

There are provided porous fibers having excellent removal performance with respect to a material to be purified; and a purification column into which an adsorbent material obtained by bundling the fibers is incorporated. The porous fibers satisfying the following conditions (a) and (b) and having a shape in which three or more projected parts are continuously present in the lengthwise direction on the periphery part of a solid-state fiber: (a) The modification degree Do/Di in a cross section is 1.2 to 6.6 when the diameter of the inscribed circle is denoted by Di and the diameter of the circumscribed circle is denoted by Do., and (b) The specific surface area of pores is 50 m/g or more.

Porous fibers, adsorbent material, and purification column

A blood purification column includes an adsorbent and a casing whose two ends are open ends, wherein the adsorbent is housed inside the casing, and wherein one of two casing ends is a blood inflow-side end portion and another is a blood outflow-side end portion, and wherein a filter is disposed at the blood inflow-side end portion and/or the blood outflow-side end portion of the casing, and wherein the filter satisfies (1)-(3):

Blood purification column

The purpose of the present invention is to provide a porous membrane that has both high water permeability and excellent protein fractionation performance. Provided is a method for producing a porous membrane, said method comprising a step for discharging a membrane-forming dope that contains a hydrophilic polymer from a slit formed in a mouthpiece, and a step for, after the passage of the discharged membrane-forming dope through a dry part, solidifying the membrane-forming dope in a coagulation bath to give a porous membrane, wherein the cross-section area of the slit is 3-30 times inclusive as large as the cross-section area of the solidified porous membrane.

Porous membrane, blood purifying module incorporating porous membrane, and method for producing porous membrane

A fiber for protein adsorption has a water absorption percentage of 1 to 50%, and the fiber includes a polymer containing as repeat units an aromatic hydrocarbon or a derivative thereof, wherein part of aromatic rings contained in the repeat units are cross-linked through a structure represented by Formula (I). A column for protein adsorption uses the fibers. A in Formula (I) is selected from an alkyl aliphatic group, phenyl aromatic group and amino group. 

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Otsu, Japan

Yoshiyuki Ueno