Kabushiki Kaisha Toshiba

Nippon Steel Sumitomo Metal Corporation

Fuji Capsule Co., Ltd.

Nippon Steel Corporation

The University of Tokyo

Wakunaga Pharmaceutical Co., Ltd.

Nisshin Kasei Co., Ltd.

Yoshiyuki Shimokawa

Naoki Nishimura

Junichi Nakagawa

Masaaki Mizuno

Kenji Kato

Tomoki Teramae

Toshiyo Yamano

Osamu Kondo

Koji Masuda

Hiroyuki Sugiyama

Osamu Goto

Hiroaki Hasegawa

Takahiro Fujimoto

Yoshihiro Suda

Kazuhiko Watanabe

Masao Hori

Katsuhiko Sekiguchi

Kimito Idemori

Hideki Minami

Satoshi Kikko

Takuya Saito

Shota Ito

Yoshihiro Shirota

Daisuke Shinagawa

Yosuke Kondo

Masuhisa Tanimoto

Hideki Sasaki

Takuji Nakai

Jun Kurihara

Sumihiro Shiraishi

Hiroshi Obayashi

Atsushi Iwamoto

Masuo Suzuki

Tetsuya Miyoshi

Manabu Udayama

Yutaka Fuwa

Yoshifumi Komura

Koichi Nishimura

Sergio Ishiba

Hitoshi Uruga

Hisayoshi Aoki

Yohsuke Yamazaki

Nahonori Inaba

Akihiko Hayano

Masahiko Aki

Koichi Ohtani

Yoshinori Hagio

Mika Mihara

Nahomi Kubo

Hiyori Iho

Isao Sato

Hiroshi Nakano

The present invention addresses a problem of providing a high quality seamless capsule, with excellent uniformity of shell thickness and virtually no eyes in the shell. The problem can be solved by manufacturing a seamless capsule using a shell composition comprising at least one polysaccharide selected from the group consisting of agar, carrageenan and gellan gum, and a PVA copolymer comprising the following structural units: (i) polyvinyl alcohol, (ii) at least one unsaturated carboxylic acid selected from the group consisting of acrylic acid, methacrylic acid, fumaric acid and maleic acid, and (iii) at least one unsaturated carboxylic acid ester selected from the group consisting of compounds represented by formula [I]:HC&#x2550;C(R)&#x2014;COOR&#x2003;&#x2003;[I](wherein Rrepresents a hydrogen atom or a methyl group, and Rrepresents an alkyl group having 1 to 4 carbon atoms).

Seamless capsule shell composition and seamless capsule

A transmission lineconfigured to be broken when it comes into contact with a railis installed on a disengagement prevention guideattached to an axle boxof a railway vehicle. One endand the other endof the transmission lineare connected to a determination unitto monitor continuity of the transmission line. In the event of a derailment, the determination unitdetermines that a derailment has occurred when the disengagement prevention guidemakes contact with the railand the transmission linebreaks, thereby interrupting the continuity of the transmission line. This arrangement allows an accurate detection of a derailment, so as to prevent a railway vehicle from traveling when its wheels have become disengaged from a rail without an operator being aware of it, thus improving safety after the derailment occurs.

Railway vehicle derailment detection method and device

An amount of wear of a railroad vehicle wheel flange online while traveling in a curved section is directly measured. A laser rangefinderis installed on an outer track side in a rounded curve section of a railroad track. When a railroad vehicle travels through the rounded curve section, the laser rangefindermeasures a distance to a front rim surface of a wheel on an outer track side of a wheelset in a forward direction of travel of a bogie forming a vehicle. The amount of wheel flange wear is obtained by comparing this measured distance with a previous measurement of the measured distance. It is then possible to control the amount of wheel flange wear when traveling in a curved section, thus making it possible to quickly find wheels having flange wear that has exceeded a control range and ensure safety during travel of the railroad vehicle.

Method for measuring wear of railroad vehicle wheel flange

An object is to provide a method of manufacturing a soft capsule that is enteric and excellent in formulation properties. An enteric soft capsule is manufactured by the following steps (a) and (b): (a) preparing an enteric capsule shell liquid comprising gelatin and low methoxyl pectin having a degree of amidation of 5 to 25%, and (b) encapsulating capsule fills using the enteric capsule shell liquid prepared in the step (a) by stamping. Preferably, the jelly strength of the gelatin is 160 to 300 Bloom, the degree of esterification of the low methoxy pectin is 20 to 40%, and the enteric capsule shell liquid comprises 30 to 35 parts by mass of the low methoxy pectin per 100 parts by mass of the gelatin.

Method of manufacturing enteric soft capsule

An object is to provide a method of manufacturing a seamless soft capsule that is enteric and excellent in formulation properties. An enteric seamless soft capsule is manufactured by the following steps (a) and (b): (a) preparing an enteric capsule shell liquid comprising gelatin and low methoxy pectin having a degree of esterification of 0 to 40% and a degree of amidation of 0 to 25%, the enteric capsule shell liquid having a viscosity at 50&#xb0; C. of 60 to 127 mPa&#xb7;s; and (b) encapsulating capsule fills with the enteric capsule shell liquid prepared in the step (a) by dripping. Preferably, the jelly strength of the gelatin is 180 to 330 Bloom, an aqueous solution of the low methoxy pectin at a concentration of 2 mass % has a viscosity at 35&#xb0; C. of 8 to 15 mPa&#xb7;s, and the enteric capsule shell liquid comprises 10 to 20 parts by mass of the low methoxy pectin per 100 parts by mass of gelatin.

Method of manufacturing enteric seamless soft capsule

A vehicle abnormality detecting apparatusincludes wheel load sensorsthat are attached to right and left rails R constituting a track to measure wheel loads of wheelsprovided in a vehicle; and a calculation unitthat is connected to the wheel load sensors. An index represented by wheel loads of a pair or more of right and left wheelsprovided in at least one of bogiesand defined according to a type of vehicle abnormality as an index for detecting the vehicle abnormality is previously stored in the calculation unit. The calculation unitcalculates a value of the stored index from the wheel loads measured by the wheel load sensorsand transmitted from the wheel load sensors, and detects the abnormality of a running vehicle based on the calculated value of the index.

Method and apparatus for detecting abnormality of vehicle

To prevent separation of a truck frame and a wheel axle and to continue supporting a vehicle, even if damage has occurred to a steering device of a steering truck in which front-back support of a steering axle is performed only by a steering mechanism. A railway vehicle steering truck provided with an axle box suspension of a steering axle, which is designed to perform support in the front-back direction of an axle box which rotatably supports the steering axle, by means of a steering device having a steering link which is rotatably connected to the axle box, and a connecting link rotatably connected to a bolster, each of these being rotatably connected to a steering lever which is rotatably connected to the a truck frame. A stopper to which the axle box comes in contact is installed both on a side where a wheelbase expands and on a side where the wheelbase contracts in the truck frame, when a front-back movement of the axle box exceeds a range of front-back movement at a time of maximum steering when the front-back movement of the axle box passes through a minimum curve.

Railway vehicle steering truck

In the event that a steering device is damaged, the damaged component is prevented from dropping onto a surface of a track or prevented from making contact with a surface of a track, even if a component to prevent dropping is not newly installed. A railway vehicle steering truck having a steering device with a steering link which is rotatably connected to an axle box which supports a steering axle, and a connecting link rotatably connected to a bolster, and these are each rotatably connected to a steering lever which is rotatably connected to a truck frame. A length A1 or A2 from one center of rotation of the steering link is shorter than a radius B of a wheel that has reached a wear limit.

A tread surface cleaning system has a cleaning element mounted to a truck frame of a steering truck in a position facing a tread surface of a wheel. The cleaning element moves freely to come into contact with and to move away from the tread surface. A pressing-load application spring biases the cleaning element toward the tread surface and a stopper restrains the cleaning element from approaching the tread surface. A forward and backward movement of a wheel axlein the travel direction caused by steering is used so that the cleaning element makes contact only on the inner rail side toward which the tread surface of the wheel approaches when passing through a curved section. The cleaning element does not make contact on the outer rail side from which the tread surface moves away when passing through a curved section and when traveling through a straight section.

A steering truck for steering a wheel axle of a truck has a solid lubricant application device at a position facing a flange of a wheel on the outer side of the wheel axle in the direction of travel in a truck frame. A solid lubricant is applied to freely make contact with and move away from the flange and a spring impels the solid lubricant towards the flange. A stopper restrains the solid lubricant from approaching the flange, By utilizing a forward and backward movement of the wheel axle in the travel direction caused by steering, the solid lubricantmakes contact only on the outer rail side toward which the wheel approaches when passing through a curved section. No contact occurs on the inner rail side from which the wheel moves away when passing through a curved section and when traveling through a straight section.

The present invention provides soft capsules comprising a capsule shell having a water activity lower than that of a capsule filling; and a production process of the soft capsules. The present invention makes it possible to prepare soft capsules without lowering the water activity of an active ingredient of a medicament or the like, which activity varies widely, depending on the active ingredient employed, leading to the provision of the soft capsules having original unimpaired properties or stability, and moreover, palatability and texture.

Soft capsules

The control system for a plant comprises a rectifier connected to a network. The rectifier has a unit for acquiring precise time, a unit for sampling the state quantity on the precise time to convert the state quantity into digital data and a unit for adding the precise time at each sampling timing to the digital data to transmit the digital data each having the precise time to the network. A breaker is connected to the network. The breaker has a unit for receiving, through the network, a control command thereto and a unit for transmitting an operating state thereof to the network. A control apparatus is connected to the network. The control apparatus has a unit for performing an operation process on the digital data transmitted through the communication network and the operating state of the breaker transmitted therethrough and a unit for transmitting the control command through the communication network to the breaker in response to a result of the control operation process of the performing unit.

Control system method of protectively controlling electric power system and storage medium storing program code

A densitometer using microwaves, which measures the density value of a to-be-measured substance in a to-be-measured liquid on the basis of a reception signal obtained by transmitting/receiving a microwave in/from the to-be-measured liquid by applicators, includes a clock source for generating a reference signal as a phase reference, an oscillator formed from a PLL circuit for generating a microwave having a frequency,in synchronism with the reference signal from the clock source, an oscillator formed from a PLL circuit for generating a microwave having a frequency f&plus;&Dgr;f in synchronism with the reference signal from the clock source, a mixer for mixing the microwave from the oscillator, i.e., a reception signal having the frequency,measured through the to-be-measured liquid with the microwave having the frequency f&plus;&Dgr;f from the oscillator, and a phase difference measuring section for comparing the phase of the output mixed by the mixer with that of the reference signal from the clock source to measure the phase difference.

Densitometer using microwaves

In a data transmission system, a plurality of control terminals or nodes used for plant control are connected to each other through a known LAN such as an ETHERNET, and a large number of control data are transmitted between the nodes at a high speed. When control data generated by each node is to be transmitted to another node, an ETHERNET frame is used as a transmission frame, and at least a plurality of blocked control data are stored on the ETHERNET frame. The control data is periodically transmitted in a multicast manner, each node includes a control data memory, and the control data is transmitted by using the memory.

Data transmission system used for plant control and based on local area

In a distance measuring apparatus, a plurality of line beams transmitted from a light source irradiate objects to form a plurality of images on the objects. Linear light sensors receive the plurality of images and generate a plurality of electric signals corresponding to the quantity of received light. A distance calculator portion carries out a product-sum operation using a predetermined function based on the plurality of electric signals, estimates a function to approximate a location of an image from a result of the product-sum operation, and calculates a distance to the object. Thus, the distance to the object can be measured at high speed and with high precision.

Optical distance measuring apparatus and method therefor

Growing community of inventors

Tokyo, Japan

Yoshiyuki Shimokawa