Riken Corporation

University of Virginia Patent Foundation

Hisamitsu Pharmaceutical Company, Inc.

The Kitasato Institute

Mitsubishi Pharma Corporation

National Institute of Technology and Evaluation

Yoshiyuki Sakaki

Masahira Hattori

Satoshi Omura

Hiroyuki Osada

Hiroshi Horikawa

Haruo Ikeda

Akira Nakagawara

Shunji Takahashi

Hajime Ishikawa

Makoto Kawatani

Atsushi Toyoda

Hajime Tei

Shin Yamazaki

Michikazu Abe

Ri-ichi Takahashi

Jun Ishikawa

Tadayoshi Shiba

Hidemi Watanabe

Shuji Shigenobu

A bacterium belonging to the genushaving an ability to produce reveromycin A or a synthetic intermediate thereof, the bacterium being modified so as to increase expression of revQ gene coding for the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence having an identity of not less than 80% to SEQ ID NO: 36 as compared with a parent strain, thereby the above-mentioned production ability is increased as compared with the parent strain.

Process for producing reveromycin A or a synthetic intermediate thereof, process for producing compounds containing a spiroketal ring and novel antineoplastics, fungicides and therapeutic agents for bone disorders

The present invention relates to an isolated Period 1 (Per1) promoter DNA inducing rhythmical expression of a gene operably linked thereto. This invention also provides a DNA comprising a Period 1 promoter DNA and a gene operably linked thereto, the gene being under the regulation of the promoter DNA. The present invention further provides transformants and transgenic mammals into which the DNA has been introduced. The transformants and transgenic mammals are useful in the screening of pharmaceutical drugs against diseases and disorders pertaining to the circadian rhythm.

Transgenic mammals introduced a Period 1 promoter that confers rhythmical expression

Novel polynucleotides derived from microorganisms belonging to actinomycetes and fragments thereof, polypeptides encoded by the polynucleotides and fragments thereof, polynucleotide arrays comprising the polynucleotides and fragments thereof, recording media in which the nucleotide sequences of the polynucleotide and fragments thereof have been recorded which are readable in a computer, and use of them.

Polynucleotides

Human BMCC1 protein having an amino acid sequence set forth in SEQ ID NO:1 in the Sequence Listing and its variant protein, as well as human BMCC1 gene having a base sequence set forth in SEQ ID NO:2 in the Sequence Listing and its variant gene.

Human BMCC1 gene

Genome DNA of bacterial symbiont of aphids

Growing community of inventors

Yokohama, Japan

Yoshiyuki Sakaki