Komatsu Corporation

Daiichi Sankyo Company, Limited

Kobe University

Kobe Gakuin Educational Foundation

Yoshiyuki Onishi

Makoto Koizumi

Yuji Kasuya

Masakazu Tamura

Takako Niwa

Mitsuhiro Aoki

Kyohei Kuroda

Jun Kobayashi

Takeshi Masuda

Kenjiro Shimada

Makoto Mori

Tsutomu Nagata

Masahiro Kurihara

Kengo Noguchi

Masamichi Kishida

Shinya Kanou

Shota Furukawa

Naoyuki Omuro

Yoshitaka Nakamura

Kentaro Ito

Chikashi Shike

Masafumi Matsuo

Mitsuhiro Iwamoto

Yuuichi Nemoto

Shinnosuke Tsuji

Kousei Shimada

Noriaki Kojima

Yukiko Sekiguchi

Shintaro Hamada

Kiyosumi Takaishi

Eri Tokumaru

Yukito Furuya

Kazumoto Iijima

Kandai Nozu

Toyohito Uchizono

Shinya Kano

Akemi Shono

Tomomi Adachi

In a construction method using an excavator that is controlled by manual operation, and an excavator that includes an automatic working-equipment control unit automatically controlling second working equipment on the basis of at least one of a current terrain and a designed terrain of a construction range in a construction site, and a tooth-edge position of the second working equipment, a progress rate that indicates a volume of soil having been excavated by the excavator to a target volume of soil to be excavated by the excavator in the construction range is calculated, and when the progress rate is equal to or larger than a threshold, the excavator stops construction of the construction range, and the excavator takes over the construction of the construction range, from the excavator.

Construction method and construction system

Provided is a simulation system capable of improving productivity in a construction site. The simulation system includes: a current topography data acquisition unit that acquires current topography data indicating a current topography of a construction site; a design topography data acquisition unit that acquires design topography data indicating a design topography of the construction site; a basic unit data acquisition unit that acquires basic unit data indicating specifications of resources related to construction in the construction site; a construction amount data calculation unit that calculates construction amount data indicating a construction amount in the construction site on the basis of the current topography and the design topography; a construction condition setting unit that sets construction condition data indicating construction procedures; and a simulation unit that calculates a transition state of the construction site on the basis of the basic unit data, construction condition data, and construction amount data.

Simulation system and simulation method

The present invention establishes a molecular therapy for glycogen storage disease type Ia. The present invention provides an oligonucleotide of 15-30 bases comprising a nucleotide sequence complementary to die cDNA of G6PC gene with c.648G>T mutation, wherein the oligonucleotide comprises a sequence complementary to a region comprising any site between the 82to the 92nucleotide from the 5′ end of exon 5 of the G6PC gene with c.648C>T mutation, a pharmacologically acceptable salt or solvate thereof. Also provided is a pharmaceutical drug comprising the oligonucleotide, a pharmacologically acceptable salt or solvate thereof (e.g., therapeutic drug for glycogen storage disease type Ia).

Therapeutic agent for glycogen storage disease type IA

A control apparatus for work machines includes a position designation reception unit configured to identify designation of a position with respect to a state image displayed on a display panel and a screen control unit configured to perform screen control according to an image displayed at the position that has been identified, among partial images constituting parts of the state image.

Reproduction apparatus, analysis assistance system, and reproduction method for synchronizing reproduction of a construction machine model

The work state identifying unit identifies a work state of a work machine disposed in a construction site at each time point and a work state of a transport vehicle traveling at the construction site at each time point. The time chart generation unit that generates a time chart representing the work state of the work machine at each time point and a time chart representing the work state of the transport vehicle at each time point on the basis of the identified work states. The output control unit that outputs the time charts on an identical screen with a time axis as a common axis.

Construction site management device, output device, and construction site management method

A topographic information transmission device which is provided in a construction site includes an image data reception unit that receives a plurality of pieces of image data in which a landform of the construction site is captured, a three-dimensional data creation unit that creates three-dimensional data of the construction site on the basis of the plurality of pieces of image data, an amount-reduction processing unit that performs an amount reduction process of reducing a total data amount of the created three-dimensional data, and a topographic information transmission unit that transmits amount-reduced three-dimensional data having undergone the amount reduction process to an information providing device.

Topographic information transmission device, construction management system, and topographic information transmission method

The present invention aims at establishing a molecular therapy for Alport syndrome. The present invention provides an oligonucleotide of 15-30 bp comprising a nucleotide sequence complementary to the cDNA of COL4A5 gene, wherein the oligonucleotide is capable of inducing skipping of an exon which has a truncating mutation found in COL4A5 gene in Alport syndrome patients and whose nucleotide number is a multiple of 3, a pharmaceutically acceptable salt thereof, or a solvate thereof. Also provided is a pharmaceutical drug comprising the above oligonucleotide, a pharmaceutically acceptable salt thereof, or a solvate thereof (therapeutic drug for Alport syndrome).

Therapeutic drug for Alport's syndrome

A work state identifying unit identifies work states of a work machine. A parameter identifying unit identifies a parameter related to a work amount per unit time of the work machine or a parameter related to a speed of the work machine for each of the identified work states on the basis of a time series of position data, azimuth data, or speed data of the work machine.

Parameter identifying device, simulation device, and parameter identifying method

An entry direction determination unit determines whether or not an entry direction of a vehicle into an output determination region is a predetermined direction in a case where the vehicle is located in a predetermined region or at a predetermined point. An output unit determines whether or not predetermined information is to be output on the basis of whether or not the entry direction is the predetermined direction.

Vehicle management device, vehicle management method, and program

An operation information transmission device transmits a state of each work medium performing work in a construction site (F) to an information providing device. The operation information transmission device includes an image data acquisition unit that acquires image data including the work medium, a type/state specifying unit that specifies the type and a state of the work medium included in the image data, and an operation information transmission unit that transmits operation information indicating the specified type and state of the work medium to the information providing device.

Operation information transmission device, construction management system, operation information transmission method, and program

A position/pose acquisition unit acquires a position and a pose of a viewpoint in a real space. A site data disposition unit disposes site data which is three-dimensional data representing a shape of a construction site in a virtual space on the basis of the position and the pose of the viewpoint. A machine data disposition unit disposes machine data which is three-dimensional data representing a shape of a work machine at a position corresponding to the site data in the virtual space. A rendering unit renders the disposed machine data.

Display control device, display control method, program, and display system

The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.

Cationic lipid

A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein Rrepresents a C1 to C6 alkyl group which may be substituted by one to three groups selected from substituent group A, or the like (substituent group A: a hydroxy group, a halogeno group, a cyano group, a nitro group, an amino group, a carboxy group, a C1 to C3 alkyl group, etc.); R, R, and Reach independently represent a hydrogen atom or a C1 to C3 alkyl group; R, R, R, R, R, and Reach independently represent a hydrogen atom or the like; and Rrepresents a hydrogen atom or the like, has TAFIa enzyme inhibitory activity and is useful as a therapeutic drug for myocardial infarction, angina pectoris, acute coronary syndrome, cerebral infarction, deep vein thrombosis, pulmonary embolism, or the like.

Cyclopropanecarboxylic acid derivative

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Tokyo, Japan

Yoshiyuki Onishi