Pola Chemical Industries, Inc.

Other

Pola Chemical Industries Inc., Japan

Yoshiyuki Miyata

Masakazu Sakaguchi

Toshimitsu Suzuki

Tomoyuki Mori

Tsutomu Takeuchi

Seiki Kobayashi

Takeshi Yamamoto

Makoto Kimura

Akira Suzuki

Takayuki Namiki

Masato Inazu

Masayuki Yanagi

Nobuyuki Kawakatsu

Toshihiro Morimoto

Kazunori Harada

Hiroaki Takayanagi

Yuji Yoshiko

Yoko Sato

Yoshiharu Momota

Ryoko Yokota

Tetsuo Katoh

Yumiko Osa

Yumiko Suzuki

Dibenzosuberanyl piperazine derivatives represented by the following formula (I):wherein R represents an aliphatic hydrocarbon group, which may contain one or more heteroatom-containing substituent groups and may preferably contain 2 to 30 carbon atoms, and physiologically acceptable salts thereof; and medicinal compositions containing these dibenzosuberanyl piperazine derivatives and/or physiologically acceptable salts thereof. These compounds show effectiveness in allowing resistance-acquired causes of diseases to restore sensitivity to drug, that is, a resistance overcoming effect.

Dibenzosuberanyl piperazine derivatives and drug-resistance overcoming agents containing the derivatives

Diphenylpiperazine derivative and drug for circulatory organ containing

Disclosed herein is an antiprotozoal composition containing a 2-nitroimidazole derivative as its active component. This drug is especially useful against Trypanosoma cruzi. Process for the preparation is also disclosed.

Antiprotozoal composition containing a 2-nitroimidazole derivative and

2-nitroimidazole derivative, production thereof, and radiosensitizer

A novel heterocyclic derivative of formula (I): ##STR1## wherein R.sub.1 represents ##STR2## and R.sub.2 represents hydrogen or acyl. When R.sub.2 is acyl, the derivative can be prepared, for example, by the following process: ##STR3## wherein R.sub.4 is acyl and R.sub.1 is ##STR4## The derivative is less toxic and has radiosensitizing activity and antiviral activity even at a low concentration. Radiosensitizing agents and antiviral agents containing the derivative as active component are also disclosed.

Heterocyclic derivatives useful as radiosensitizing agents and antiviral

Heterocyclic derivatives and radiosensitizing agents and antiviral

Growing community of inventors

Yokohama, Japan

Yoshiyuki Miyata