Tanabe Seiyaku Company, Limited

Mitsubishi Tanabe Pharma Corporation

Yoshiyuki Koida

Masayoshi Samejima

Goichi Hirata

Akira Kida

Hiroshi Miura

Masaaki Sugimoto

Hideki Murakami

Kiyoshi Harada

Yoshinori Kobayashi

Intraorally rapidly disintegrating tablets which, when ingested, disintegrates in the oral cavity rapidly without presenting unpleasant taste, can be quickly absorbed in the digestive tract and express efficacy are provided. The intraorally rapidly disintegrating tablets contain a drug being hardly water-soluble under neutral or alkaline conditions and being highly water-soluble under acidic conditions yet presenting unpleasant taste, which tablets can be prepared by combining the medicinal substance with a water-soluble acidic substance, coating either or both of the substances with a water-soluble coating agent being insoluble in alcoholic solvent, further adding a water-soluble binding agent being soluble in alcoholic solvent and a water-soluble saccharide, subjecting the resultant mixture to compression, and treating the products with an alcoholic solvent.

Tablets quickly disintegrated in oral cavity

Pharmaceutically active compound-containing microcapsules the coating walls of which consist essentially of ethylcellulose and a water-insoluble, acid-soluble polymer material are disclosed. A method of preparing said microcapsules is also disclosed.

Process for preparing ethylcellulose microcapsules

Ethylcellulose microcapsules, wherein a polymer material which shows at least 1.2 times increase in weight by immersing it in water at 37.degree. C. is incorporated into the ethylcellulose coating walls and/or the core material thereof, are disclosed. Said ethylcellulose microcapsules show rapid release of the core material in digestive organs such as stomach.

Microcapsules and method of preparing same

A process for preparing ethylcellulose microcapsules of a pharmaceutically active compound by phase separation-coacervation of the ethylcellulose is disclosed. In this process, phospholipids are used as a phase-separation-inducing agent.

Process for preparing pharmaceutically active compound-containing

A stable, oil-in-water type, fine particle, fatty emulsion which is regulated with a pH value regulator consisting of an organic amine and a buffer solution to a pH value of 6.0 to 8.0, said fatty emulsion having a fatty particle size of not larger than 2.mu.. The fatty emulsion can stably be kept for a long period of time without lowering of the pH value and aggregation of the fatty particles.

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Katano, Japan

Yoshiyuki Koida