Tanabe Seiyaku Company, Limited

Yoshiyuki Hirakawa

Hiroyuki Yoshino

Kazuo Noda

Masayoshi Samejima

Eiji Fukui

Tami Hanamori

Hiroshi Miura

Toshiyuki Ueki

Seiichi Morikuni

Katsuji Uemura

Keiichi Kohno

Shinji Narisawa

A pharmaceutical preparation for oral administration which is controlled to release a medicinal active ingredient at a targeted site in the intestinal tract comprising (a) a core containing a medicinal active ingredient and (b) a press-coated layer comprising an enteric polymer, said layer being provided around the core. In the pharmaceutical preparation of the present invention, the medicinal active ingredient is not released during residence in the stomach and, after discharged from the stomach, until reaching a targeted site in the intestine, and thereafter is quickly released, so that the medicinal active ingredient is efficiently delivered to the targeted site in the intestinal tract.

Pharmaceutical preparation controlled to release medicinal active

A pharmaceutical preparation for oral administration comprising

A controlled release pharmaceutical preparation comprising (a) a core containing a pharmaceutically active substance and an organic acid, and (b) a coating film formed on the surface of the core by aqueous coating of a water-insoluble and water-slightly permeable acrylic polymer containing a trimethylammonium-ethyl group, which exhibits well controlled dissolution and release of the pharmaceutically active substance when administered and can maintain the desired blood level of the active substance for a long period of time, and a method for producing the preparation.

Controlled release succinic acid microcapsules coated with aqueous

Disclosed is a controlled release pharmaceutical preparation, comprising a core containing a pharmaceutically active ingredient, and a porous film of a hydrophobic polymeric substance or a hydrophobic polymeric substance and a hydrophilic polymeric substance, the core being coated with the porous film. Disclosed is also a method for producing the same. The controlled release pharmaceutical preparation of this invention posseses a desired dissolution rate by controlling the porosity of the porous film.

Controlled release pharmaceutical preparation and method for producing

An antibacterial lyophilized preparation which comprises as an active ingredient aspoxicillin and a basic salt of aspoxicillin in a molar ratio of 1 : about 0.7 to 7 and optionally an alkali metal halide as a stabilizer, and a method for preparing the same, said antibacterial lyophilized preparation being able to be rapidly dissolved in distilled water to give a stable solution which can be injected to patients for the treatment of various bacterial infectious diseases.

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Toyonaka, Japan

Yoshiyuki Hirakawa