Ishihara Sangyo Kaisha, Ltd.

Yoshiyuki Aoyama

Nobutoshi Yamada

Keizo Miyata

Masanari Kato

Hiroshi Shikama

Hiroshi Kikugawa

Shigeo Murai

Yasuo Morishima

Hiroshi Sasaki

Makiko Mitani

Soichiro Nagayama

A pyridonesulfonylurea compound of the formula (I) or its salt: ##STR1## wherein Q is ##STR2## for use as a herbicide, wherein the variables are hereinbelow defined.

Pyridonesulfonylurea compounds, process for their production and

A polypeptide which is a tumor necrosis factor polypeptide having an amino acid sequence represented by from the 1st Ser to the 155th Leu as shown by SEQ ID NO:1 in the Sequence Listing, or its mutein, wherein the amino acid sequence of the 1st Ser to the 8th Asp of the SEQ ID NO:1 or the corresponding amino acid sequence of the mutein is replaced by an amino acid sequence containing at least one amino acid sequence of Arg-Gly-Asp and from 3 to 16 amino acids. Also disclosed are a recombinant plasmid containing a DNA encoding such a polypeptide, a recombinant microbial cell transformed by such a recombinant plasmid, a process for producing the polypeptide, a pharmaceutical composition comprising the polypeptide as an active ingredient, and a DNA for the polypeptide.

Muteins of TNF pharmaceutical compositions and a method of making

A polypeptide which is a tumor necrosis factor polypeptide having an amino acid sequence represented by from the 1st Ser to the 155th Leu as shown by SEQ ID NO:1 in the Sequence Listing, or its mutein, wherein the amino acid sequence of the 1st Ser to the 8th Asp of the SEQ ID NO:1 or the corresponding amino acid sequence of the mutein is replaced by an amino acid sequence containing at least one amino acid sequence of cell-adherent peptide of laminin and from 5 to 30 amino acids. Also disclosed are a recombinant plasmid containing a DNA encoding such a polypeptide, a recombinant microbial cell transformed by such a recombinant plasmid, a process for producing the polypeptide, a pharmaceutical composition comprising the polypeptide as an active ingredient, and a DNA for the polypeptide.

N-terminal muteins of tumor necrosis factor

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Kusatsu, Japan

Yoshiyuki Aoyama