Kao Corporation

Yoshiya Sugai

Masahide Hoshino

Hiroaki Saito

Yoshinori Nishizawa

Yoshie Shimotoyodome

Hiroshi Hashimoto

Yasushi Katayama

Junko Ishikawa

Shotaro Ito

Mituru Sugiyama

Akiyo Kameyama

Yutaka Takagi

Hiroshi Kusuoku

Akira Yamamuro

Ichiro Tokimitsu

Tadashi Hase

Koji Yoshino

Shinya Amano

Taisuke Aosaki

Akiko Kawasaki

Youichi Arai

Naoki Oya

Atsuko Otsuka

Yoriko Nakagiri

Shinichi Meguro

Shi Chen

Shino Mitsunaga

Provided are an agent for imparting ceramide-like function, an agent for reinforcing skin barrier function, a moisturizing agent and a skin drug for external use. The agent for imparting ceramide-like function comprises as an effective ingredient a derivative of succinic acid diamide represented by the following formula (1): [wherein Rand Reach independently represents a hydroxyalkyl group of from 1 to 6 carbon atoms, Rrepresents a group: &#x2014;CHCHCHCH&#x2014;Ror a group: &#x2014;CHCH&#x2550;CHCH&#x2014;R(wherein Rrepresents an alkyl group of from 8 to 26 carbon atoms)].

Ceramide-like function imparting agent

A transglutaminase activator containing at least one kind selected from the group consisting of an extract from, an extract from, and a compound represented by Formula (1), as an active ingredient: 

Transglutaminase activator

A ceramide production enhancer and a moisturizer containing, as an active ingredient, an extract of at least one plant selected from the group consisting of, and, or a compound represented by the following Formula (1): 

Ceramide production enhancer and moisturizer

Provided are a drug, a cosmetic, etc. for promoting production of ceramide. Provided is a ceramide production promoter including a compound represented by the formula (1) or salts thereof as an active ingredient (in the formula, Rrepresents a phosphono group or a hydrogen atom, Rrepresents an alkyl group having 8 to 24 carbon atoms or an acyl group having 8 to 24 carbon atoms, and Rrepresents an alkyl group having 1 to 24 carbon atoms when Rrepresents a phosphono group or represents a phosphono group when Rrepresents a hydrogen atom, or a salt thereof as an active ingredient. 

Ceramide production promoter

The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following formula (1): (wherein, Rand Rare the same or different and each represents a Chydrocarbon group, Rand Rare the same or different and each represents a divalent Chydrocarbon group, Rs are the same or different and each represents a divalent Chydrocarbon group and n stands for 1 to 100). The composition for external application, humectant and skin barrier function reinforcing agent basically improve the water retaining ability and barrier functions of the horny layer, are excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.

Composition for external application

The present invention relates to a dermatologic preparation containing a diamide derivative represented by the following formula (1): (wherein, Rrepresents a linear or branched hydrocarbon group having 1 to 22 carbon atoms which may be substituted by one or more hydroxy and/or alkoxy groups, Rrepresents a linear or branched divalent hydrocarbon group having 1 to 12 carbon atoms, and Rrepresents a linear or branched divalent hydrocarbon group having 1 to 42 carbon atoms). This diamide derivative (1) is capable of fundamentally improving the water retention capacity and barrier functions of the horny layer, is excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.

Dermatological preparations

External preparation compositions

An amide derivative represented by the following formula (1): ##STR1## wherein R.sup.1 represents a C.sub.1-40 hydrocarbon; R.sup.2 represents a C.sub.1-6 alkylene; R.sup.3 represents H, OH or alkoxyl; R.sup.4 represents a C.sub.1-39 hydrocarbon; R.sup.5 represents ##STR2## with the proviso that when R.sup.5 represents ##STR3## R.sup.3 does not represent OH; and a composition of the amide derivative for topical application to human skin. The composition improves the barrier function of the stratum corneum, providing improvement and prevention of dermatitis, skin roughness, or similar disorders.

Amide derivatives and their use in cosmetic composition

Growing community of inventors

Haga-gun, Japan

Yoshiya Sugai