Sanwa Kagaku Kenkyusho Co., Ltd.

Yoshiya Kondo

Yuichi Ozeki

Yukinao Watanabe

Masayasu Kurono

Kiichi Sawai

Takashi Ito

Makoto Sato

Noboru Kuboyama

Kazumasa Nakano

A method for manufacturing a molded article with at one or more cores uses compression molding apparatus that includes upper and lower punches that have a double structure comprising a central punch and an outer punch that surrounds the periphery of the central punch. The central punch and the outer punch are capable of independent sliding motions and compressing operations. Molding materials are supplied for a core and an outer layer respectively. The molding materials are compressed by the punches to form molded articles that include the core. The method may be executed in a rotary compression molding machine.

Method for manufacturing molded article with core

To manufacture a multi-core press-coated molded product efficiently and in a single step from molding materials, namely, powder or granular particles, a punch has been devised that is characterized in that the punch, consists of a center punch whose tip portion is split into two or more parts, and an outer punch enclosing the outer perimeter of the center punch, and whose tip portion fills the gap at the tip portion of the center punch, with both the center and outer punches being slidable and manipulatable for compression operation the method of manufacturing a multi-core press-coated molded product using the punch of the invention as compression molding means for at least the upper punch and preferably for both the upper and lower punches, and a rotary compression molding machine therefore is also discribed. This has led to the successful manufacture of a multi-core press-coated molded product in which a plurality of cores are arranged horizontally relative to the pressure applied surface of the molded product and further located at specific positions. When provided with a score line, the multi-core press-coated molded product can be made into a dividable molded product.

Method for producing multi-cored molded article

A therapeutic preparation for ulcers contains as a primary ingredient a compound having an aldose reductase inhibitory activity and can accelerate dermal metabolism. That compound may be d-6-fluoro-2,3-dihydro-2',5'-dioxo-spiro [4H-1-benzopyran-4,4'-imidazolidine]-2-carboxyamide, d-2-chloromethyl-6-fluoro-2,3-dihydro-spiro [4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione and d-2-bromomethyl-6-fluoro-2,3-dihydro-spiro [4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione.

Method of treating gastrointestinal ulcers with spiro hydantoins

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Nagoya, Japan

Yoshiya Kondo