Horiba, Ltd.

Kyoto University

Omron Corporation

Yoshito Okuno

Hidekatsu Nogami

Kazuyuki Hirao

Tatsuo Yoshida

Yasushi Nakata

Shuichi Matsui

Hirokazu Kasai

Nobuyuki Naka

Shinsuke Kashiwagi

Shiro Miyake

Kazushi Yamasaki

Masayuki Nishi

Sakiko Akaji

Hiroki Itasaka

Daisuke Irikura

Daisuke Teranishi

In a method of determining the type of each cell contained in a sample, one Raman spectrum is acquired from one undetermined cell, a plurality of degrees of matching of a Raman spectrum of the undetermined cell with respect to spectra of a plurality of principal components obtained by principal component analysis of a plurality of Raman spectra that are obtained one by one from each of a plurality of known types of cells are calculated, and a type of the undetermined cell is determined by classifying the plurality of degrees of matching based on a result obtained by classifying a plurality of principal component scores corresponding to each of the plurality of known types of cells obtained by the principal component analysis depending on the type of cells by a learning model using supervised learning.

Determination method, determination apparatus, and recording medium

A needle-shaped body protrudes from a cantilever made of Si. Furthermore, the rear face of the cantilever is coated with aluminum (first metal) having a Fermi level higher than that of Si. The cantilever is dipped into an aqueous silver nitride solution containing the ions of Ag serving as a second metal. The electrons of Si flow out to the aqueous silver nitride solution due to the existence of the aluminum, and Ag nanostructures are precipitated at the tip end of the needle-shaped body. A probe for tip-enhanced Raman scattering in which the Ag nanostructures are fixed to the tip end of the needle-shaped body is manufactured. The sizes and shapes of the Ag nanostructures can be controlled properly by adjusting the concentration of the aqueous silver nitride solution and the time during which the cantilever is dipped into the aqueous silver nitride solution.

Probe manufacturing method and probe

Growing community of inventors

Kyoto, Japan

Yoshito Okuno