Gunze Limited

Kyocera Corporation

Kuraray Co., Ltd.

Other

Dow Corning Corporation

Teijin Limited

Asahi Kasei Kogyo Kabushiki Kaisha

Daicel Chemical Industries, Ltd.

Denki Kagaku Kogyo Kabushiki Kaisha

Gc Corporation

Santen Pharmaceutical Co., Ltd.

Research Development Corporation of Japan

Menicon Co., Ltd.

Jms Co., Ltd.

G-c Dental Industrial Corp.

Yoshito Ikada

Shokyu Gen

Suong-Hyu Hyon

Hiroo Iwata

Masakazu Suzuki

Waro Taki

Sen Yamagata

Yasuhiro Yonekawa

Tatsuo Nakamura

Tomohiko Asahara

Koji Yamauchi

Masanori Oka

Hideaki Okimatsu

Tsuguyoshi Taira

Yasuo Shikinami

Ichiro Ando

Shingo Emi

Yasuhiko Shimizu

Hiroyasu Suzuki

Yuki Sakamoto

Takao Kubota

Kazuo Imamura

Shinichiro Morita

Ikuo Kyotani

Kazuhiko Sakai

Tatsuya Kawai

Takeshi Shimamoto

Shojiro Matsuda

Yoshimi Tanaka

Shigehiko Suzuki

Kaoru Tsuta

Hidekazu Boutani

Masao Okada

Koichi Tamura

Haruo Kimura

Toshiharu Shinoka

Hajime Handa

Susumu Miyamoto

Keisuke Yamada

Kenji Tomihata

Yoshihiko Shimizu

Yoshikiyo Saito

Goki Matsumura

Shigeo Ohi

Hideki Tadokoro

Hikaru Konishi

Michiaki Yoshimoto

Yoshitake Takahashi

Yuichiro Ogura

Hideji Kagawa

Yasuhiko Tabata

Tsuneo Cho

Hiroyuki Kawashima

Yosuke Urabe

Hyu H Suong

Satoshi Watanabe

Eugene Corretge

Toshiyuki Okada

Akio Kurishita

Isao Nogami

Junichi Ohashi

Aoi Nishizawa

Kyoji Suzuki

Naoki Kondo

Sosuke Kimura

Kazuaki Hori

The present invention provides a tissue regeneration substrate that has the ability to release a basic fibroblast growth factor (bFGF) and like cell growth factors in a sustained manner, into which cells can easily enter, and that is suitably used for regeneration of tissues. Specifically, the present invention provides a tissue regeneration substrate that comprises a cell growth factor adsorbed in a bioabsorbable porous substrate that contains collagen and gelatin, and a method for producing the same.

Tissue regeneration substrate

An antiadhesive material that is excellent in biocompatibility and bioabsorbability, as well as excellent strength in suturing and bonding, is provided. A reinforcing materialmade of a biodegradable polymer is placed in a gelatin solution so that the reinforcing materialis impregnated with the solution, and the gelatin is caused to gelate and dried. By so doing, an antiadhesive material in which a gelatin filmand the reinforcing materialare integrated is obtained. The reinforcing materialpreferably is arranged in a portion of the gelatin filmto be subjected to suturing, and preferably is arranged along a periphery of the gelatin film. The gelatin filmpreferably is a cross-linked gelatin film, and the reinforcing materialpreferably is a nonwoven fabric.

Antiadhesive material

The present invention provides an artificial dura mater characterized by comprising at least a sheet of a biodegradable and bioabsorbable synthetic polymer and having a storage modulus at ordinary temperature of from 1&#xd7;10to 5&#xd7;10(Pa); and a process for producing an artificial dura mater characterized by dissolving a lactide/&#x3b5;-caprolactone copolymer (in a molar ratio ranging from 40/60 to 60/40) in a solvent, filtering the resultant solution and casting the same followed by air drying.

Artificial dura mater and process for producing dura mater

The present invention provides an artificial dura mater characterized by comprising at least a sheet of a biodegradable and bioabsorbable synthetic polymer and having a storage modulus at ordinary temperature of from 1&times;10 to 5&times;10 (Pa); and a process for producing an artificial dura mater characterized by dissolving a lactide/&egr;-caprolactone copolymer (in a molar ratio ranging from 40/60 to 60/40) in a solvent, filtering the resultant solution and casting the same followed by air drying.

An artificial cornea comprising an optical element made of an optically transparent material, having a front surface and a posterior surface, and a skirt provided so as to support with surrounding at least a part of the optical element, characterized in that the skirt is provided with a flange on its side facing the interior of eyes during implantation of the artificial cornea and the flange radially protrudes outward from the skirt. The artificial cornea can be well compatible with ocular tissue, prevent leakage of intraocular aqueous humor and intraocular invasion of bacteria, reduce stimulation on palpebral conjunctiva and further, inhibit progression of the down growth, and which has no possibility of reduction in transparency of the optical element due to the down growth as well as detachment and extrusion from the implanted state.

Artificial cornea

The invention provides an artificial dura mater comprising a sheet made of bioabsorbable synthetic polymers formed from copolymers of lactic acid and .epsilon.-caprolactone.

Artificial dura mater

The present invention relates to a scleral plug made of lactic acid copolymer; a scleral plug containing a drug that is designed to gradually release the drug into a vitreous body; and a scleral plug that is used to treat or prevent diseases of the retina or to promote recovery from damage after vitreous surgery taking advantage of its sustained release action for drug delivery.

Biodegradable scleral plug

A bio-degradable/absorbable barrier membrane is coated thereon with sucrose esters of fatty acids. The sucrose esters of fatty acids is one or more members selected from the group consisting of monoester, diester, and polyester. The fatty acid is one or more members selected from the group consisting of stearic acid, palmitic acid, lauric acid, and myristic acid. These higher fatty acids may be mixed with a lower fatty acid.

Bio-degradable/absorbable barrier membrane

A cellulosic polymer wherein at least a part of the hydroxyl groups of the cellulosic polymer is modified as represented by the following general formula [I]: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each represents a hydrogen atom or a C.sub.1 to C.sub.5 alkyl group, X is a strong negative atomic group, and Y is ##STR2## wherein R.sup.3 and R.sup.4 may be the same or different and each represents a member selected from the group consisting of a hydrogen atom, a C.sub.1 to C.sub.5 alkyl group and a C.sub.3 to C.sub.6 cycloalkyl group, or ##STR3## Y is wherein R.sup.5, R.sup.6 and R.sup.7 may be the same or different and each represents a member selected from the group consisting of a hydrogen atom, a C.sub.1 to C.sub.5 alkyl group, a C.sub.3 to C.sub.6 cycloalkyl group and a C.sub.6 to C.sub.10 aryl group, and n is from 1 to 10. Using the cellulosic polymer, a blood-treating device is assembled.

Cellulosic polymer, blood-treating device, and process for producing the

A prosthesis used for a damaged bone, an artificial articular cartilage or an artificial intervertebral disc being characterized in that the prosthesis is a composite body comprising polyvinyl alcohol hydrogel and ceramic or metallic porous body. With this prosthesis, PVA hydrogel enhances lubrication and shock absorbing functions, and the porous body allows the ingrowth and ossification of the bone tissue of a living body therein to affinitively connect said hydrogel to the bones of the living body.

Artificial intervertebral disc

Artificial bone connection prosthesis

Disclosed are a crosslinked gelatin microspheres containing CSF and a water soluble CSF-gelatin conjugate. Both the microspheres and the water soluble conjugate provide an improved CSF stability. They have a high potentiation on the antitumor activity of macrophages in respect of the CSF amount and the time required for macrophage activation and are effective in maintaining their activated state for a long period, compared with the native CSF. The mechanism of macrophage activation by the microspheres containing CSF is mediated via phagocytosis and different from that by native CSF, which is believed to activate macrophages via cell surface receptor. The species specificity of CSF may be abrogated when the CSF is internalized into macrophages through phagocytosis.

Colony stimulating factor-gelatin conjugate

A periodontium-regenerating material for the regenerative treatment of the periodontium consists of bio-degradable/absorable copolymers of lactide/.epsilon.-caprolactone or lactide/glycolide having a weight-average molecular weight of 40,000 to 500,000 as well as a dynamic modulus of 5.times.10.sup.7 to 5.times.10.sup.9 dynes/cm.sup.2 and a elongation rate of 100 to 2,000 %, both measured at room temperature (25.degree. C.). Those copolymers may be used in the form of a sheet or film which may or may not be porous.

Periodontium-regenerative materials

The invention provides a marine fishery article of threads which is made of threads consisting essentially of polycaprolactone represented by the formula ##STR1## wherein n is 300 to 2,000.

Marine fishery thread articles

Biodegradable and resorbable surgical materials of molded articles of poly(lactic acid) or copolymers of lactic acid and glycolic acid, characterized in that the articles are molecular-orientated, and having a bending strength of 1.6.times.10.sup.33 to 2.5.times.10.sup.3 kg/cm.sup.2, a bending modulus of 5.5.times.10.sup.2 to 24.0.times.10.sup.2 kg/cm.sup.2, a crystallinity, determined by density measurement, of 10 to 60%, and a viscosity average molecular weight measured after melt processing of not less than 200,000, and in that at least 80% of initial strength of the articles is maintained after dipping in a saline at 37.degree. C. for three months.

Biodegradable and resorbable surgical material and process for

Growing community of inventors

Uji, Japan

Yoshito Ikada