Fujisawa Pharmaceutical Company, Ltd.

Astellas Pharma Gmbh

Yoshiteru Eikyu

Hisashi Takasugi

Shinji Shigenaga

Kazuhiko Take

Fumiyuki Shirai

Hidenori Azami

Kazuo Nakai

Kohji Kawabata

Yuki Sawada

Yoshikazu Inoue

Shigeki Satoh

Nobukiyo Konishi

Shinya Okuda

Naoki Ishibashi

Kazunori Kamijo

Masataka Morita

Yasuharu Urano

Junya Ishida

Koichiro Mukoyoshi

Hirofumi Yamamoto

Hiroshi Miyake

Hideo Tsutsumi

Natsuko Kayakiri

Takashi Manabe

Chiyoshi Kasahara

Tadashi Terasaka

Hiromichi Itani

Yoshihiro Kozuki

Hiroshi Sasaki

Taro Masunaga

This invention relates to novel N-hydroxyacrylamide compounds of formula (I) and pharmaceutically acceptable salts thereof. More particularly, it relates to novel N-hydroxyacrylamide compounds and pharmaceutically acceptable salts thereof which act as a HDAC inhibitor, to a pharmaceutical composition comprising the same and to a method of using the same therapeutically in the treatment and/or prevention of HDAC-related disease. 

Pyrazinyl hydroxyacrylamide compounds having an inhibitory effect on the activity of histone deacetylase

Compounds having the formula (I): wherein

HDAC inhibitor

A compound having the formula (I): wherein

This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.

Piperazine derivatives

This invention relates to piperazine derivatives of the formula:wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.

Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists

A compound of the formula (I): in which Z, R , R , R , R , R , R , R and R are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.

Benzhydryl derivatives

A compound of the formula: ##STR1## wherein R.sup.1 is amino or protected amino,

Cephem compounds

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Tokyo, Japan

Yoshiteru Eikyu