Nihon Nohyaku Co., Ltd.

Yoshitami Oshita

Masanori Yoshida

Masashi Nagamine

Makoto Gotoh

Kazuo Kanai

Masanobu Onishi

Takuya Motokawa

Takashi Kagawa

Akiyuki Satoh

Koji Umimoto

Pyridazinone derivatives

Pyridazinone derivatives of formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a methyl group which may be substituted with an aliphatic cyclic amino group optionally containing a hetero atom in the ring thereof; each of X.sup.1 and X.sup.2 independently represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a cyano group, a nitro group or a group shown by --CO--NR.sup.2 R.sup.3 (wherein each of R.sup.2 and R.sup.3 independently represents an alkyl group having 1 to 6 carbon atoms); Y represents a halogen atom; Z represents an alkoxy group having 1 to 6 carbon atoms; l represents 0 or an integer of 1 to 3; A represents CH or N; m represents 0 or an integer of 1 or 2; and n represents an integer of 1 to 8, exhibit a platelet aggregation inhibiting activity and are useful for the treatment of circulatory disorders such as cerebral infarction.

Pyridazinone derivatives, processes for production thereof and use

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Osaka, Japan

Yoshitami Oshita