Chugai Seiyaku Kabushiki Kaisha

Yoshitake Kanbe

Masahiro Nishimoto

Kazumi Morikawa

MyungHwa Kim

JaeChon Jo

Jaeyoung Choi

HeeAn Kwon

Jong Min Kim

Yoshikazu Nishimura

JongMin Kim

Ju Su Kim

Hyun Suk Lim

Jae Chon Jo

Myung Hwa Kim

PilSu Ho

HyunSuk Lim

SungOh Ahn

YoungJun Na

HongIl Heo

Hirokazu Hamada

SungDae Park

Tatsuo Miyauchi

HongKi Kim

Akira Koda

JuSu Kim

KooHyeon Ahn

The present invention provides a compound consisting of a moiety and a group chemically bonded to said moiety, wherein said moiety contains a compound having low activity following oral administration or its parent scaffold and said group has the following general formula (1): in which

Compounds with hydroxycarbonyl-halogenoalkyl side chains

The present invention relates to a novel benzopyran or thiobenzopyran derivative represented by formula (1): pharmaceutically acceptable salt or stereoisomer thereof, in which X, R, R, R, Rand A are defined as described in the specification, and to a process for preparation thereof and a pharmaceutical composition having anti-estrogenic activity which contains the compound (1) as an active component.

Benzopyran or thiobenzopyran derivatives

Compounds with hydroxycarbonyl-halogenoalkyl side chain

Optically active chroman and thiochroman derivatives

The present invention relates to 3-methyl-chromane or thiochromane derivatives, pharmaceutically acceptable salts, stereoisomers or hydrates thereof, and an anti-estrogenic pharmaceutical composition which comprises the above compound as an active component.

3-methyl -chromane or thiochromane derivatives

3-ethyl-, 3-propyl- or 3-butyl-chroman and thiochroman derivatives

3-methyl-chroman and -thiochroman derivatives

Compounds represented by the general formula (I): ##STR1## (where R.sub.1 is an admantyl group; R.sub.2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or an aralkyl group; R.sub.3 is a 1,4-benzodioxane ring that may optionally have 1-4 substituents selected from among a lower alkyl group, a lower alkoxy group, a halogen atom, an amino group, a hydroxyl group and a lower alkylcarbonyl group; n is an integer of 1-4) or a salt thereof. These compounds have both antianxiety and antidepressant actions and yet they cause less side effects. Therefore, they can be used as excellent drugs that are highly effective in the prevention and treatment of various diseases such as neurosis. psychosomatic diseases, autonomic imbalance and depression.

Benzodioxane derivatives

Growing community of inventors

Shizuoka, Japan

Yoshitake Kanbe