Shionogi Company Limited

Other

Yoshitaka Tomoda

Yusuke Suzuki

Toshitada Toyoda

Toyohiko Takeda

Nagayoshi Myo

Yasushi Takagishi

Toshiro Fujii

Kazuhiro Shima

Hisayoshi Kato

Takayuki Tsukada

Takashi Hayashi

Koji Sato

Ikuo Tanai

Noboru Nagafuzi

Yoichi Taniguchi

Kazuaki Yoshioka

The present invention relates to a process for producing a spherical particle comprising an aggregate of particles containing at least 95% of a water-soluble single substance having a viscosity of 10 mPa.s or less as determined in the form of a saturated aqueous solution, the process comprising: preparing moist spherical particles of the single substance by charging, as cores, crystalline particles or granulated particles of the single substance on a rotary disc in a processing vessel of a centrifugal tumbling granulating apparatus, wherein the granulated particles are prepared by granulating a powder of the single substance, and dispersing over the cores a powder of the single substance and simultaneously spraying on the cores a liquid such as water or the like while supplying slit air to provide a fluidized condition; and then fixation treating the moist spherical particles by drying them while spraying an aqueous solution of the single substance or the like on the spherical particles in a fluidized bed apparatus; to the spherical particle produced by the process; and to a pharmaceutical preparation and a food containing the spherical particle.

Spherical single-substance particles, medicines and foodstuffs containing the particles, and method of production thereof

The centrifugal fluidizing granulator for powder coating granulation has a sensor for detecting changes of viscosity of the growing particles by means of a load cell or a displacement detector; and output signal of the sensor is compared with the data stored in a memory contained in a control unit which determines whether the growing particles are in their wetted state or dried state. The control unit controls the spraying of the liquid and the dispersion of the guest powder based on the result of the comparison.

Centrifugal fluidizing granulator for powder coating granulation

A process for preparing a coated composition comprising a pharmaceutically active substance stable to heat, which comprises centrifugally granualting a mixture comprising said active substance and a first thermomelting material as a binder under heating without using any solvent and coating the resultant granules with a second thermomelting material as a coating material under heating, the melting point of the second thermomelting material being lower than that of the first thermomelting material.

Coated composition and its preparation process

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Daitoh, Japan

Yoshitaka Tomoda