Msd K.k.

Yoshitaka Tamai

Jun Kusunoki

Katsuya Ohbuchi

Naomi Murai

Yoshiki Ito

Yukina Tokushima

Katsumi Aragane

Naomoto Harada

Takaharu Maruyama

It is an object to provide a gene-modified non-human animal having inactivated MGAT2 gene and a gene-modified non-human animal cell, which are useful for the search of the function of MGAT2 in vivo. It is another object to provide a method for screening of a compound capable of inhibiting the activity of MGAT2 and a compound capable of inhibiting the activity of MGAT2. It is further another object to provide a method for detecting a disease induced by abnormal lipid metabolism based on the expression level or activity of MGAT2. A method for screening of a compound by using a gene-modified non-human mammal having the artificially inhibited expression of MGAT2 gene and a cell thereof enable to prevent or treat a disease induced by abnormal lipid metabolism. Also a screening of a compound capable of inhibiting or enhancing the function of MGAT2 enables to prevent or treat a disease induced by abnormal lipid metabolism.

Animal having modification in MGAT2 gene

Growing community of inventors

Tsukuba, Japan

Yoshitaka Tamai