California Institute of Technology

Yoshitaka Numajiri

Brian M Stoltz

Koji Chiyoda

Beau P Pritchett

Douglas Duquette

Kelly E Kim

Marc Liniger

Alexander N Marziale

Robert A Craig

This invention provides enantioenriched Mannich adducts with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.

Enantioselective synthesis of &#x3b1;-quaternary Mannich adducts by palladium-catalyzed allylic alkylation

Enantioselective synthesis of &#x3b1;-quaternary mannich adducts by palladium-catalyzed allylic alkylation

This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II) or (III): with a palladium (II) catalyst under alkylation conditions.

Asymmetric catalytic decarboxylative alkyl alkylation using low catalyst concentrations and a robust precatalyst

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Kamakura, Japan

Yoshitaka Numajiri