Fujitsu Corporation

Daiichi Sankyo Company, Limited

Fujitsu Media Devices Limited

Sankyo Company, Limited

Meiji Co., Ltd.

Other

Arqule, Inc.

Meiji Dairies Corporation

Tokyo Roki Co., Ltd.

Amukon Kabushikikaisha

Amcon Na, Inc.

Amcon Europe S.r.o.

Yoshitaka Nakamura

Osamu Tsuboi

Norinao Kouma

Ippei Sawaki

Hisao Okuda

Satoshi Ueda

Hiromitsu Soneda

Mi Xiaoyu

Yoshihiro Mizuno

Makoto Yamaguchi

Makoto Yamaoka

Masakazu Wakayama

Shinya Nagafuchi

Takeshi Takahashi

Masaki Terahara

Takafumi Kitawaki

Toyonori Takebayashi

Yukito Furuya

Yoshihiro Kanamaru

Hideo Ohtomo

Kenichi Nakazawa

Takeshi Kaneda

Naoyuki Kishi

Narumi Abe

Hiroshi Ishikawa

Fumio Yamagishi

Masayuki Murakami

Kazuo Kaneko

Noritada Sato

Yoshiyuki Onishi

Sumio Yamada

Kosaku Ishida

Yutaka Kitagawa

Takashi Iwase

Makoto Imai

Hiroshi Tokunaga

Katsunori Kimura

Shuji Ikegami

Kiyoshi Yamada

Kazuo Tanaka

Kazutoshi Ukai

Kousei Shimada

Kenichi Kimura

Takatsugu Kurosawa

Seiko Narushima

Masako Yajima

Kenji Nagata

Yuki Kadowaki

Eiji Numagami

Makoto Michida

Yusuke Tezuka

Sen Minemura

Masaya Wada

Kazuki Shirakura

Yuta Endo

Jun Takashima

Takumi Nakajima

Jo Ooyama

Kazuhiro Umeo

Ayako Saito

Itaru Moro

Kuniyasu Ochiai

Mamoru Totsuka

Toshihiko Onoda

Tadahiro Takeda

Hirokazu Kobayashi

Masayoshi Jin

Toshihiro Sashihara

Yoshihiro c/o Faculty Of Agriculture Kanamaru

Itaruv Moro

An object of the present invention is to provide an optically active bicyclic &#x3b3;-amino acid derivative in a high purity. The object can be attained by a mixture of compounds represented by the general formulas (I) and (I'), or a method for producing a compound represented by the general formula (VII) or a salt thereof via the compound (I): wherein Rand Reach represent a C1-6 alkyl group or the like; and Rrepresents a cyano group or the like, 

Preparation method for optically active bicyclic gamma-amino acid compound

The problem to be solved is to provide a method for efficiently producing compounds (1) and (1a) that are important intermediate compounds in the production of FXa inhibitors (X) and (X-a). The solutions thereto are a method for producing a compound represented by the formula (8d) using a stereoselective intramolecular cyclization reaction, and a method for producing a compound (1f) or a salt thereof, or a hydrate thereof, which is characterized by desulfonylation of the compound (8d). In each formula, Rrepresents a C1-C6 alkyl group, a benzyl group, etc. 

Preparation method of optically active diamine compound

An object of the present invention is to efficiently produce an optically active bicyclic compound. The optically active bicyclic compound is efficiently produced using an enzyme.

Optical resolution methods for bicyclic compounds using enzymes

A solid-liquid separation device includes a plurality of fixed members and movable members that are movably disposed between the adjacent fixed members, and a screw extending through the fixed members and the movable members in a state where the screw is not in contact with the fixed members and the movable members. The screw is rotationally driven about a center axis line thereof. A filtrate separated from an object is discharged to the outside of the solid-liquid separation portion through filtrate discharge gaps, and the object that has a reduced liquid content ratio is discharged from the outlet to the outside. In order to increase significantly a dewatering ratio, the movable members are formed to move while penetrating closer to the center axis line of the screw than an outer circumferential edge of the blade of the screw, without coming into contact with the screw.

Solid-liquid separation device

A probioticwas discovered from lactobacilli of thegenus independently isolated from human adult feces. The probioticwas selected from other bacterial strains for: (1) being highly resistant to gastric acid/bile acid; (2) having a high promoting activity on IL-12 production from mouse derived spleen cells and a high Th1/Th2 balance-improving effect; (3) having a high ability to inhibit the production of antigen-specific IgE induced by intraperitoneally administering ovalbumin to BALB/c mice; (4) having a high ability to inhibit the production of antigen-specific IgE induced by orally administering a food antigen to C57BL/6N mice; (5) having a high Natural Killer cell-activating ability; (6) having a high IL-12 production-promoting activity on spleen cells and mesenteric lymph node cells derived from mice immunized with ovalbumin and a high Th1/Th2 balance-improving effect; and (7) having a high ability to suppress eosinophilia induced by a cedar pollen-extracted antigen. This discovery led to the completion of the present invention.

Immune function modulating agents

A method of manufacturing a compound represented by the formula RC(OR), wherein Rrepresents a C-Calkyl group and Rrepresents a C-Calkyl group by reacting a compound represented by the following formula (15): wherein Rrepresents a C-Calkyl group, Rrepresents a C-Calkyl group and X represents Cl, Br, I, HSOor NO, with a compound represented by the formula R&#x2014;OH, wherein Rrepresents a C-Calkyl group, in a solvent which forms a bilayer system.

Method for manufacturing neuraminic acid derivatives

[Problem to be Solved] To enhance the performance for separation of oil mist from blow-by gas. [Solution] A filter elementwhich is to be attached to an oil separator unitincludes a core. This core is a double tube having an internal cylindrical memberand an external cylindrical member, and a space between the internal cylindrical member and the external cylindrical member is used as a separation chamber. An injection holefor injecting blow-by gas while increasing its flow velocity is provided in the internal cylindrical member. A surface which is an inner wall surface of the external cylindrical member and which faces the injection hole is a spraying surface onto which the blow-by gas injected from the injection hole is sprayed. Moreover, an opening for oil discharge from which oil OL condensed on the spraying surface is discharged, and an opening for discharge from which the blow-by gas from which oil mist has been separated is discharged are provided in the core.

Oil mist separator

The problem to be solved is to provide a method for producing a compound having excellent activity as an &#x3b1;&#x3b4; ligand. The solution thereto is a method for producing a compound represented by the general formula (VI) or a salt thereof via an iminium salt: [in the formula, R: a hydrogen atom or a C1-C6 alkyl group]. 

Methods for producing bicyclic compounds via iminium salt

The problem to be solved by the present invention is to provide a method for producing a compound having excellent activity as an &#x3b1;&#x3b4; ligand. The solution thereto is a method for producing a compound represented by the general formula (VI) or a salt thereof using rearrangement reaction: [in the formula, R: a hydrogen atom or a C1-C6 alkyl group] 

Methods for producing bicyclic compounds via claisen rearrangements

An optically active bicyclic compound is efficiently produced by optical resolution using an optically active amine.

Optical resolution methods for bicyclic compounds using asymmetric catalysts

The present invention relates to highly-pure pyrroloquinolinyl-pyrrole-2,5-dione and pyrroloquinolinyl-pyrrolidine-2,5-dione, for example, 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione, 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione, and pharmaceutically acceptable salts, solvates, and diastereomers thereof. The present invention also relates to methods for preparing highly-pure pyrroloquinolinyl-pyrrole-2,5-dione and pyrroloquinolinyl-pyrrolidine-2,5-dione, for example, 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione, 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione, and pharmaceutically acceptable salts, solvates, and diastereomers thereof.

Highly pure pyrroloquinolinyl-pyrrole-2,5-dione and pyrroloquinolinyl-pyrrolidine-2,5-dione and methods of preparing same

An object of the present invention is to provide a pyrrole derivative useful as an immunosuppressive agent and a method for producing the same. For achieving the object, the present invention provides a method for producing a compound represented by the general formula (I) by heating a compound represented by the general formula (III) and a compound represented by the general formula (IV) in a nonpolar solvent under reduced pressure. 

Pyrrole derivative and process for production thereof

Methods for manufacturing neuraminic acid compounds and synthetic intermediates of neuraminic acid compounds, including a method for manufacturing a compound represented by wherein Rrepresents a C-Calkyl, Rrepresents a C-Calkyl, Rand Rrepresent a hydrogen atom, a C-Calkyl or a phenyl, or Rand Rtogether form a tetramethylene, a pentamethylene or an oxo, and Ac represents an acetyl, comprising reacting a compound represented by wherein Rrepresents a C-Calkyl, Rrepresents a C-Calkyl, Rand Rrepresent a hydrogen atom, a C-Calkyl or a phenyl, or Rand Rtogether form a tetramethylene, a pentamethylene or an oxo, with trimethylsilyl azide in the presence of a Lewis acid.

The present inventors discovered that microfiltration retentates of whey, and products obtained by treating whey using centrifugation and/or ammonium sulfate precipitation, have the activity of inhibiting rotavirus infection. In one embodiment, the present invention provides a method of preventing rotavirus infection, comprising administering to a subject a composition that comprises a whey cream serum obtained by treating whey by centrifugation, or a dehydrated product thereof, wherein the antiviral activity of said composition is retained after heat treatment.

Compositions against rotavirus infection and processes for producing the same

The present inventors discovered that microfiltration retentates of whey, and products obtained by treating whey using centrifugation and/or ammonium sulfate precipitation, have the activity of inhibiting rotavirus infection.

Growing community of inventors

Kanagawa, Japan

Yoshitaka Nakamura