Mochida Pharmaceutical Co., Ltd.

Merck Sharp + Dohme Corp.

Honda Motor Co., Ltd.

Dai Nippon Printing Co., Ltd.

Terumo Kabushiki Kaisha

Yoshitaka Maeda

Tsutomu Satoh

Takashi Mizuno

Cameron James Smith

Jiayi Xu

Ting Zhang

Hiroshi Nagasue

Tomokazu Hirabayashi

Dann Parker

Yasushige Akada

Tomoyuki Kamino

Naoto Kosuga

Daido Hotta

Hideharu Uchida

Isao Sakurada

Ken-ichi Amano

Ryohei Takeuchi

Masatoshi Kuroda

Kouichirou Yori

Suguru Fukuda

Kazumasa Yamaki

Ryoma Bise

Fumiya Ohashi

Ken-Ichi Amano

The present disclosure is intended to provide an internal combustion engine that can inhibit fuel from adhering to a piston and can reduce generation of soot. An internal combustion engine includes a piston, a cylinder accommodating the piston, and an injector including a nozzle that has a plurality of nozzle holes configured to inject fuel into the cylinder from above the cylinder. Among the plurality of nozzle holes, a sixth nozzle hole an axial direction of which is the most deflected toward the piston has a nozzle hole diameter larger than nozzle hole diameters of the other nozzle holes, and the nozzle hole diameter of the sixth nozzle hole corresponds to at least 20% of the total of the nozzle hole diameters of the other nozzle holes.

Internal combustion engine

[Problem] To evaluate objective cell groups by estimating a mixing ratio of objective cell group without affecting treatment itself and its production process when the objective cell groups include plural kinds of cell groups having different attributes, and to provide an image analysis system and a culture management system capable of accurately perform a quality control and a production control with low cost. [Solution] The cell quality evaluation systemdetects a feature amount in each cell easily analyzable from images, and estimates a mixing ratio of each of plural kinds of cell groups included in the objective cell groups based on a distribution of the detected feature amount and pre-recorded information of the feature amount. As the feature amount, the embodiment uses a migration speed of each cell, easily distinguishable by analyzing tracking of each cell from plural images in time series.

Image analysis system, culture management system, image analysis method, culture management method, cell group structure method, and program

In its many embodiments, the present invention provides a novel class of benzamide compounds represented by Formula (I) or pharmaceutically acceptable salts or solvates thereof, or pharmaceutical compositions comprising one or more said compounds or pharmaceutically acceptable salts or solvates thereof, and methods for using said compounds or pharmaceutically acceptable salts or solvates thereof for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes. 

Factor IXa inhibitors

A compound represented by formula (I'): (wherein m, n, and p each represent 0 to 2; q represents 0 or 1; Rrepresents halogen, a hydrocarbon group, a heterocyclic group, an alkoxy group, an alkoxycarbonyl group, a sulfamoyl group, a CN group, an NOgroup, or the like; Rrepresents halogen, amino, a hydrocarbon group, an aromatic heterocyclic group, or an oxo group; Xrepresents O, &#x2014;NR&#x2014;, or &#x2014;S(O)r-; Xrepresents a methylene group, O, &#x2014;NR&#x2014;, or &#x2014;S(O)r-; Q&#x2032; represents a heteroaryl group, a heteroarylalkyl group, a substituted aryl group, or an aralkyl group; Cycle moiety represents an aryl ring or a heteroaryl ring; and the wavy line represents an E-isomer or a Z-isomer), a salt of the compound, or a solvate of the compound or the salt. A pharmaceutical composition and a transient receptor potential type I (TRPV1) receptor antagonist each contain, as an active ingredient, at least one of the compound, a salt of the compound, and a solvate of the compound or the salt.

Heterocyclidene acetamide derivative

Growing community of inventors

Tokyo, Japan

Yoshitaka Maeda