Hitachi-high-technologies Corporation

Hitachi, Ltd.

Hitachi High-tech Corporation

Applied Biosystems, LLC

Yoshitaka Kodama

Motohiro Yamazaki

Ryoji Inaba

Shigeru Matsui

Kazuo Takeda

Muneo Maeshima

Takashi Anazawa

Tomohiro Shoji

Satoshi Takahashi

Hitoshi Komuro

Miho Ozawa

Koji Tomita

Hiromi Yamashita

Takeshi Ohura

Manabu Akiba

Takamichi Muramatsu

Shuhei Yamamoto

Eric S Nordman

Kunio Harada

Masaya Kojima

Taro Nakazawa

Takanobu Haga

Yuichiro Ota

Isao Nemoto

Yukari Sahoyama

Tatsuya Yamashita

Provided are: a device for storing biochemical reagents wherein an amount of a reagent can be hermetically stored and dropped from a storage site without coming into contact with the outside air; and a biochemical analyzer using the device. The device () is constituted by: sticking a top sheet () to a base sheet () provided with a convex-shaped hollow pocket () in which a reagent can be housed; a reagent container as a PTP packaging sheet () wherein an opening of the pocket in the base sheet (), in which a reagent is preliminarily housed, is hermetically sealed with the top sheet (); and sticking the film sheet surface as the top sheet () of the PTP packaging sheet (), in which the reagent is hermetically packaged, to a cartridge surface of a device body () to thereby hermetically seal the inside of the device body too.

Device for storing biochemical reagents, and biochemical analyzer

A multicolor detection device includes: a condensing lens arrayin which a plurality of condensing lenseseach of which turns light emitted from each of a plurality of light emitting pointsindividually into parallel light beams, are arranged, the light emitting points being arranged in a light emitting point array; at least one spectroscopic element on which the parallel light beams are incident in parallel, the at least one spectroscopic element being common; and at least one sensor on which light beams spectrally separated by the spectroscopic element are incident in parallel, the at least one sensor being common.

Multicolor detection device

During analysis of samples of unknown concentration, situations frequently occur in which the dynamic range is insufficient, necessitating reanalysis. Accordingly, a fluorescence spectrometer which splits a single object image into multiple images having different fluorescent intensity by means of image splitting elements, and simultaneously detects the plurality of images obtained thereby in different regions within the same detection plane, is proposed.

Fluorescence spectrometer

A multicolor detection device includes: a condensing lens arrayin which a plurality of condensing lenses, each of which turns light emitted from each of a plurality of light emitting pointsindividually into parallel light beams, are arranged, the light emitting points being arranged in a light emitting point array; at least one spectroscopic element on which the parallel light beams are incident in parallel, the at least one spectroscopic element being common; and at least one sensor on which light beams spectrally separated by the spectroscopic element are incident in parallel, the at least one sensor being common.

A laser beamirradiated from a side face of a microchipin which plural channelsfill ed with a member of a refractive index nin an inner portion of a member of a refractive index n(n&#x3c;n) are arranged in parallel with the same plane, along the same plane is refracted in a direction of being directed from an upper base to a lower base in a case where a section of the channelis configured by a trapezoidal shape of upper base&#x3e;lower base, and is deviated swiftly from a channel array. Hence, the laser beamis made to be deviated gradually from the channel array by irradiating the laser beamfrom the side face of the microchipby being inclined relative to the same plane in a direction of being directed from the lower base to the upper base. As a result, a larger number of the channelscan efficiently be subjected to laser beam irradiation.

Multichannel analysis device

A nucleic acid analysis device which can determine a DNA sequence has a flowcell in which two or more DNA fragment clusters of two or more DNA fragments having identical nucleotide sequences are immobilized. At least a part of the flowcell is made of a transparent material. An irradiation unit irradiates a part in which the DNA fragment clusters are immobilized. The device has a lens for collecting fluorescence, and a light-detection element. A solution containing only dATP having a fluorescently modified phosphate terminal among four bases, a solution containing only dCTP having a fluorescently modified phosphate terminal among the four bases, a solution containing only dGTP having a fluorescently modified phosphate terminal among the four bases, a solution containing only dTTP having a fluorescently modified phosphate terminal among the four bases, and a buffer solution are sent sequentially to where the DNA fragment clusters are immobilized.

Nucleic acid analysis device

To allow fully automated implementation of all steps of from pre-processing up to electrophoresis. Provided is a pre-processing/electrophoresis integrated cartridge including one or more block structures corresponding to the individual steps of pre-processing. Each block structure includes (1) a first block having a reaction tank, a reagent tank, a plurality of flow channels that connect the tanks, a plurality of control valves arranged in the flow channels, and a flow channel that connects a reaction tank in a block structure located at a preceding stage and a reaction tank in a block structure located at a next stage, and (2) a second block having a phoretic solution tank, a cathode buffer solution tank, a wash solution tank, a flow channel that connects a carrier tank in the block structure located at the preceding stage and the phoretic solution tank, and a control valve for the flow channel.

Pre-processing/electrophoresis integrated cartridge, pre-processing integrated capillary electrophoresis device, and pre-processing integrated capillary electrophoresis method

The invention provides a capillary electrophoresis apparatus which can improve the operability and measuring speed. According to the invention, a sensor for identifying the type of sample containers is fixed at the position away from a capillary anode electrode. The sensor is made to be closer to the sample containers by moving a moving stage so that the sample containers disposed on the moving stage can be identified by the sensor. A fixing apparatus for fixing at least a pair of sample containers is provided on the moving stage.

Capillary electrophoresis apparatus

When irradiating laser beam from the side face of the capillary array, an optical axis of the laser beam is inclined in vertical direction with respect to a plane face formed by the capillary array, thus, reflection light by the capillary array and returning light is prevented from entering into a laser beam source, thereby, instability of laser oscillation is eliminated.

Capillary array electrophoresis apparatus

A multi-capillary electrophoresis apparatus is provided for reducing errors during analysis caused by fluctuations in electrophoresis time among plural capillaries of the apparatus. The multi-capillary electrophoresis apparatus can contain a multi-capillary array that has a separation medium filled therein for isolating a sample. A detector component can be provided at a position remote from a sample injecting end of the array for acquiring information from the sample. A buffer container can be provided for holding a buffer solution into which the sample injecting end can be immersed. One or more temperature controlling component devices can be arranged for controlling a temperature of the buffer solution, of the detector component, or of both the buffer solution and the detector component.

Multi-capillary electrophoresis apparatus

A defect inspection apparatus for detecting defects existing on a surface of a semiconductor sample and/or inside the sample based on light information from the sample obtained by irradiating a light beam onto the sample is provided, which comprises a detecting means for detecting positions in the depth direction where the defects exist and distribution of the defects based on the light information; a setting means for setting a position in the depth direction where defects exist; and a means for displaying the distribution of the defects obtained by the detecting means, the displaying means displaying the distribution of the defects corresponding to the position in the depth direction set by the setting means.

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Tokyo, Japan

Yoshitaka Kodama