Osaka University

Chugai Seiyaku Kabushiki Kaisha

Kagami Inc.

Yoshitaka Isaka

Hiroshi Ohno

Tomonori Kimura

Masashi Mita

Kenji Hamase

Shinji Fukuda

Kenichiro Iio

Shiro Takahara

Keiko Yasuda

Enyu Imai

Yasuyuki Nagasawa

The purpose of the present invention is to provide: a method for predicting the prognosis for kidney disease for a subject on the basis of the amount of D- and L-amino acids, from a blood sample; and an analysis system that determines prognosis predictions. This purpose is achieved by using at least one amino acid to predict the prognosis for kidney disease, said amino acid being selected from the group consisting of D-serine, D-asparagine, D-proline, D-alanine, D-leucine, D-lysine, D-allo-isoleucine, L-glutamic acid, L-alanine, L-tryptophan, and L-asparagine.

Kidney disease prognosis prediction method and system

A process for detecting presumed IgA nephropathy by detection ofbacteria and/orbacteria present in a sample from the tonsil of a subject who, optionally, has a positive result in a urinary protein test and/or a urinary occult blood test, or whom is diagnosed with possible IgA nephropathy. Also, a process for detecting an IgA nephropathy patient for whom tonsillectomy is effective by detectingbacteria or Campylobacter bacteria.

Method for detecting presumed IgA nephropathy and method for screening IgA nephropathy patients

The present invention provides a method for gene transfer through the vascular system or a ureter. In a preferable embodiment of this invention, an aqueous solution containing an expression vector comprising a desired gene is injected through the vascular system or a ureter of a desired organ to introduce the gene into the injected area. Specifically, the method of the present invention is effective for ex vivo gene therapy wherein the hepatocyte growth factor (HGF) gene is introduced by electroporation into a kidney to be transplanted. According to the present invention, the HGF functions continuously on the kidney to be transplanted, and the HGF within the treated area does not affect other organs of the body. Thus, the method of the present invention is a safe and effective treatment for maintaining the survival of transplanted kidneys.

Method of gene transfer via vascular system or ureter

Growing community of inventors

Osaka, Japan

Yoshitaka Isaka