Osaka University

Fujita Health University

Other

Medical Biological Laboratories Co., Ltd.

Institute for Antibodies Co., Ltd.

Kurosawa, Yoshikazu

Yoshitaka Iba

Yoshikazu Kurosawa

Yoshinobu Okuno

Nobuko Ohshima

Yasushi Akahori

Nobuhiro Takahashi

Kazuhiro Suzuki

Keiko Ogawa

Gene Kurosawa

Kimiyasu Shiraki

Kazuhiro Morishita

Yoshinori Ukai

Motohide Takahashi

Mariko Sumitomo

Masachika Azuma

Sari Fujiyama

Atsushi Sugioka

Kazuhiko Morino

Chiho Muramatsu

Kazuki Matsuda

Susumu Tsustumi

Miwa Morita

Akihiko Takasaki

Nobuhiro Hayashi

Midori Shinohara

Atsushi Viequ Court Denjiyama Sugioka

Nobuhiro c/o The Faculty Of Agriculture Takahashi

Susumu Tsutsumi

Masachika c/o Inst Antibodies Co Ltd Azuma

Yoshinori c/o Inst Antibodies Co Ltd Ukai

Kazuhiro Miyazaki Medical College Dept Of Biochemistry Morishita

Provided is an anti-influenza virus antibody that exhibits neutralizing activity beyond the barrier of the two groups of influenza viruses categorized according to the conservativeness of hemagglutinin amino acids, a method of producing the same, and a test method for determining whether the subject carries the neutralizing antibody.

Influenza virus-neutralizing antibody and screening method therefor

An antibody library is prepared by selecting a light chain variable region capable of binding to the variable region of heavy chain to reproduce an active conformation and using the same. Because of being capable of maintaining the diversity of the heavy chain variable region at a high ratio in vitro, the antibody library of the present invention is expected as enabling the acquisition of antibodies with various binding activities.

Antibody library

It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.

Anti-IgSF4 antibody and utilization of the same

Growing community of inventors

Aichi, Japan

Yoshitaka Iba