Other

Perseus Proteomics Inc.

Chugai Seiyaku Kabushiki Kaisha

Yoshitaka Hippo

Hiroyuki Aburatani

Yukio Ito

Toshihiko Ohtomo

Hirotaka Ito

Hirokazu Taniguchi

Shogo Yamamoto

Shumpei Ishikawa

Yong Xin Chen

Shin-ichi Fukumoto

Takahiro Shimamura

Ying Qiu Guo

Akira Watanabe

Masahiro Arai

Yasuko Kinoshita

Naoko Kamimura

Masashi Fukayama

Hiroko Iwanari

Hirokazu Satoh

Susumu Tokita

Yutaka Midorikawa

Shin-ichi Funahashi

Shin-ichi Funahshi

Kiyotaka Watanabe

Shin Ohnishi

Naoka Kamimura

A method for diagnosing cancer comprising detecting ROBO1 protein is disclosed. In addition, a method for treating a disease caused by abnormal cell growth comprising administrating an antibody that binds to ROBO1, as well as a pharmaceutical composition, a cell growth inhibitor and an anticancer agent comprising an antibody that binds to ROBO1 as an active ingredient are disclosed. Further, a method for inducing cell damages in a ROBO1 expressing cell and a method for inhibiting the growth of a ROBO1 expressing cell by bringing a ROBO1 expressing cell into contact with an antibody that binds to ROBO1, are disclosed. Furthermore, a method for monitoring progression of hepatitis by detecting ROBO1 protein is disclosed.

Cancer diagnosis and treatment of cancer using anti-ROBO1 antibody

Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.

Gene overexpressed in cancer

Cancer diagnosis and treatment of cancer using anti-robo 1 antibody

A method for prognosing possible recurrence after treatment of the liver cancer, characterized by measuring GPC3 contained in a test sample by use of an anti-GPC3 antibody.

Method for predicting and judging the recurrence of liver cancer after treating liver cancer

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Huntington, NY, United States of America

Yoshitaka Hippo