Daiso Co., Ltd.

Osaka City University

Yoshiro Furukawa

Masafumi Mikami

Kazumasa Hinoue

Yasushi Miki

Kazuhiro Kitaori

Keisuke Yaegashi

Keishi Takenaka

Hiroshi Yoshimoto

Junzo Otera

Kousei Ikai

Yutaka Ishii

Katsuhito Miura

Toshio Suzuki

Yoshikazu Takehira

Yutaka Shiomi

Shouhei Matsui

Masanori Yanagida

Makoto Hirata

Takeshi Urano

Shigeo Katsumura

Kimitaka Igi

Takeshi Nagasaki

Seiji Ohtaka

Naotaka Kameyama

Satoshi Murakami

Tetsuya Yanagimoto

Kenichi Ishibashi

Kenji Oohata

Tatsuro Hayashi

Midori Masaki

Kenichi Nagao

The present invention provides a combination product which comprises: The combination product according to the present invention is useful as a material for a tissue adhesive hydrogel which can be used as a hemostatic agent or the like which exhibits low risks for viral infections and the like, high biodegradability and biocompatibility, excellent safety, a good adhesion rate and a good adhesion strength.

&#x3b2;-1,3-glucan-derived polyaldehyde/polyamine hydrogel

The present invention provides a method of kinetic optical resolution of carboxylic acid derivatives using specific optically active catalysts. A racemic or diastereomeric mixture of carboxylic acid derivatives of the formula (A) is reacted with a nucleophile in the presence of an optically active catalyst to form an optically active nucleophile derivative of the formula (B). The catalyst is an optically active compound represented by the formula (C) or (D) [wherein Ris a substituted or unsubstituted, saturated or unsaturated, straight-chain, branched or alicyclic aliphatic hydrocarbon group which can have a heteroatom, Ris ethyl or vinyl, and Ris hydrogen or methoxy respectively]. 

Optically active compounds, method for kinetic optical resolution of carboxylic acid derivatives and catalysts therefor

A process for producing a glycidyl ether and an optically active compound thereof with high yield and an optically high purity comprising reacting an alcohol with epihalohydrin in a base to thereby produce a glycidyl ether, the reaction performed in a two-layer system of a nonaqueous organic solvent and an aqueous solvent.

Process for producing glycidyl ether

A process for producing a &#x3b2;-hydroxyester by reacting an epoxide, an alcohol and carbon monoxide in the presence of a cobalt carbonyl compound as catalyst, which is characterized in using as co-catalyst, a pyridine derivative having an amino substituent of formula (1),  wherein Rand Rare independently hydrogen, formyl, acyl, alkoxycarbonyl, substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, or Rand Rmay be taken together with the adjacent nitrogen atom to form a ring, and n is an integer of 1 or 2.

Process for producing &#x3b2;-hydroxyester

A process for preparing glycidylphtalimide or it optically active compound by reacting a phthalimide alkalimetal salt with an epihalohydrin or an optically active epihalohydrin in an alcohol solvent; or by reacting phthalimide with an epihalohydrin or an optically active epihalohydrin in the presence of an alkali metal carbonate, an alkali metal hydrogencarbonate or a quaternary ammonium salt to obtain a N-(3-halogeno-2-hydroxypropyl)phthalimide and then by cyclizing the product with an alkali metal alkoxide.

Process for preparing glycidylphthalimide

An object of the present invention is to provide a process wherein 1,2,4-butanetriol can be obtained safely, easily and inexpensively without causing problems concerning wastewater. A malic diester, 3-hydroxy-&#x3b3;-butyrolactone or 3,4-dihydroxybutanoate represented by the following formulae (I), or a mixture thereof is reduced with sodium borohydride in an organic solvent to give 1,2,4-butanetriol represented by the following formula (II). When an optically active substance is used as the above-mentioned starting compound, substantially no recemization occurs during the reduction, and optically active 1,2,4-butanetriol is obtained.

Process for preparing 1,2,4-butanetriol

A process for preparing regioselectively an optically active 1-halogeno-2-hydroxypropyl compound of the following formula;

Process for preparation of optically active halogeno hydroxypropyl compound and glycidyl compound

Process for producing butanetriol derivative

The present invention relates to a process for reacting &agr;-aminoaldehyde derivatives having a sterically bulky amino group which are commercially available with a metal cyanide in the presence of an acid chloride, an acid anhydride or the like to synthesize 3-amino-2-hydroxybutyronitrile derivatives in high yields and high erythro selectivity. When optically active &agr;-aminoaldehyde derivatives are used, racemization hardly occurs during the reaction, and the desired products are obtained in high optical purity.

Process for producing erythro-3-amino-2-hydroxybutyric acid derivatives

An industrial process for preparing an oxazolidin-2-one derivative represented by the following general formula (3)

Process for producing oxazolidin-2-one derivative

A process for preparing a 3-hydroxy-&ggr;-butyrolactone derivative represented by the following formula (1):

Process for producing 3-hydroxy-&ggr;-butyrolactone derivatives

Polyether copolymer, solid polymer electrolyte and battery

Process for producing 1,2-propanediol

Process for preparation of 1,3-dioxolane-4-methanol compounds

Growing community of inventors

Osaka, Japan

Yoshiro Furukawa