Fujisawa Pharmaceutical Company, Ltd.

Yoshio Ueda

Fumio Shimojo

Kazutake Kado

Takehisa Hata

Sotoo Asakura

Yoshio Murakami

Hiroshi Ishikuro

Satoshi Ueda

Rinta Ibuki

Toshinobu Uemura

Toshiyasu Honbo

Atsuo Ohike

Toshiomi Nakate

Hisami Yamaguchi

Kenichi Nishimura

Kiyohide Shinooka

Takayoshi Honda

Masateru Kodani

Yasuo Shimazaki

Kiyoshige Yoshida

Toshiaki Okhuma

Eiji Shiba

Yoshiaki Mochizuki

The present invention relates to a pharmaceutical composition for percutaneous drug absorption which comprises 5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and ethanol and/or an unsaturated higher fatty acid and to a composition of matter which comprises ethanol and/or an unsaturated higher fatty acid and is capable of promoting percutaneous absorption of said dihydropyridine compound.

Pharmaceutical composition for percutaneous drug absorption and

This invention relates to a solid dispersion composition comprising FR-900506 substance and water-soluble hydroxypropyl methylcellulose which is capable of dispersing the FR-900506 substance, the FR-900506 substance and hydroxypropyl methylcellulose being in the ratio of 1:0:1 to 1:20 by weight.

Solid dispersion composition of FR-900506 substance

Sustained-release percutaneous preparations which have at least two adhesive layers and in which a drug is contained in the layer farthest from the skin and a solid powder is dispersed in an adhesive layer other than the layer farthest from the skin provide slow release of the drug. By varying the kind and concentration of the solid powder, the rate of release of the drug from the preparations can be controlled.

Sustained-release percutaneous preparations

The invention relates to a Time-Controlled Explosion System in which drug release is caused by explosion of a membrane after a definite time period, said System comprising a preparation in the form of a bead or granule, said preparation comprising a core, a drug, swelling agent and an outer membrane of water-insoluble coating material.

Time-controlled explosion systems and processes for preparing the same

A tablet printing machine provided with a roll soiling detecting unit for optically detecting soiling of the surface of a roll of its printing unit. The machine is further provided with a roll cleaning unit including a cleaner to be impregnated with a cleaning liquid and adapted for pressing contact with the transfer roll of the printing unit during the rotation of the roll.

Tablet printing machine with roll cleaning system

The invention relates to a sustained-release transdermal delivery preparation which comprises a slow-release microcapsule containing 2-nitroxymethyl-6-chloropyridine or its occlusion compound with .beta.-cyclodextrin and a skin-compatible base.

Sustained-release transdermal delivery preparations

The invention relates to a pharmaceutical oral capsule preparation filled with a substantially anhydrous mixture which is in solid or semi-solid form comprising:

Novel drug carrier and pharmaceutical preparation comprising the same

An occlusion compound of 2-nitroxymethyl-6-chloropyridine with .beta.-cyclodextrin is disclosed herein as well as a process for preparing the occlusion compound thereof. The occlusion compound of the present invention has a molar ratio of 2-nitroxymethyl-6-chloropyridine to .beta.-cyclodextrin of between about 1:1 and about 3:1. The present occlusion compound is nonvolatile, thereby overcoming the problems associated with the volatility of the 2-nitroxymethyl-6-chloropyridine for pharmacuetical preparations. The process of the present invention is carried out by reacting 2-nitroxymethyl-6-chloropyridine with .beta.-cyclodextrin either by kneading both compounds together with a small amount of a solvent or by mixing both compounds in an appropriate solvent, such as water. The occlusion compound is then precipitated, separated and further purified by conventional methods.

Occlusion compound of 2-nitroxymethyl-6-chloropyridine with

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Kobe, Japan

Yoshio Ueda