Kowa Company Limited

Yoshio Takahashi

Masami Shiratsuchi

Toshiaki Oda

Takeo Deushi

Masahiro Tamura

Seiichi Sato

Mitsuteru Hirata

Takeshi Ohshima

Tomio Ohta

Hiroyuki Sonoki

Yukihiro Okuno

Kimiyuki Shibuya

Yoshinori Kyotani

Hiroyuki Ishiwata

Kazuhiro Onogi

Hiromichi Shigyo

Yasumi Uchida

Hamao Umezawa

Tetsuya Ishikawa

Takashi Yamaguchi

Tadaaki Ohgiya

Yasushi Wada

Hendrik Timmerman

Tsutomu Toma

Masahito Nakayama

Kiyoshi Kawamura

Katsumi Kawamine

Hiroshi Ishihama

Toru Kanke

Noboru Shimizu

Koichiro Watanabe

Jiro Matsumoto

Tsutomu Tohma

Hisakatsu Itoh

Mingqiang Zang

Mikio Fujii

Masaji Oono

Sadahiro Shimizu

Katsuhiro Yamamoto

Pyrimidine derivatives

The present invention is directed to a piperidine derivative represented by the following formula (1) or a salt thereof: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 individually represent hydrogen atoms, etc., Y represents ##STR2## B represents a single bond, an alkylene group, --S--CH.sub.2 --, or --CH.dbd.CH--, E represents a single bond or a trimethylene group, Z represents an oxygen atom, etc., and n represents a number between 2 and 5 inclusive; and to a medicine containing the compound. The medicine according to the present invention is endowed with excellent anti-histaminic activity and antileukotriene activity, and exhibits reduced side effects such as drowsiness.

Piperidine derivatives

Pyrimidine derivatives as endothelin antagonists

Azoxy compound

An indole derivative represented by formula (1), ##STR1## wherein A is a group ##STR2## wherein R.sup.10 is hydrogen or lower alkyl, dotted lines may optionally be present, and R.sup.1 -R.sup.9 represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.

Indole derivatives, salts thereof, and congestive heart failure

Diamine compound and brain protecting agent containing the same

A compound expressed by the formula: ##STR1## in which R.sub.11, R.sub.21 and R.sub.31 are identical with or different from each other and each denotes a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, a haloalkyl group, an alkoxy group, an alkylthio group, an aryl or an aralkyl group which aromatic ring is optionally substituted appropriately by one to three substituents or a heterocyclic group optionally substituted appropriately by one to three substituents, or R.sub.11 and R.sub.21 may together form an alkylene group, Y denotes O or NOH, with a proviso that where R.sub.21 (or R.sub.11) and R.sub.31 denote a hydrogen atom at the same time, R.sub.11 (or R.sub.21) cannot represent an n-butyl group. This compound is useful as an antifungal agent.

Azoxy compounds

A substituted anilide derivative of the formula ##STR1## wherein R.sub.1 represents a mononuclear or binuclear heterocyclic group which contains 1 to 3 nitrogen atoms as ring members and may have a substituent.

Substituted anilide compounds which are useful in the treatment of

An azetidine derivative of the formula, ##STR1## wherein R is a hydrogen atom or a hydroxyl group, and R.sub.a, R.sub.b, R.sub.c, R.sub.a ', R.sub.b ' and R.sub.c ' are identical or different and each are a lower alkyl group.

3-Alkylidine azetidine compound and their production

Growing community of inventors

Iruma, Japan

Yoshio Takahashi