Takeda Chemical Industries, Inc.

Yoshio Sugiyama

Yukihiro Kanegae

Mitsuru Kawada

Isamu Nakatsui

Hiroyuki Miya

Hideki Kizawa

Kenichiro Miyagawa

Kanshiro Minami

A microorganism belonging to the Gram-positive cocci having not less than about 55 mol % of guanine plus cytosine content of DNA is cultivated in a medium. Trehalose is produced and extracellularly accumulated in the medium with a good yield. The present method, therefore, brings about a feasible method for the industrial production of trehalose. Preferably, the microorganism used is Deinococcus proteolyticus (IFO 15345), Deinococcus erythromyxa (IFO 15344), Deinococcus radiopugnans (IFO 15348), Micrococcus varians (FERM BP-4238 and IFO 3765), Micrococcus agilis (IFO 15323) or Microccus luteus (IFO 3067 and IFO 12708).

Method for the production of trehalose using strains of Micrococcus and

In a fermentive production of polyglutamic acid and a salt thereof, the accumulation of polyglutamic acid can be markedly increased in a very simple manner by adding an alkaline earth metal ion to the medium in a concentration of not less than 0.05 mole per liter.

Method for producing polyglutamic acid or a salt thereof

Method for producing (2R,3S)-3-hydroxy-2-methylbutyrate by microbial

A (1R,2S)-2-hydroxycycloalkanecarboxylic acid ester is efficiently and selectively produced by microbial asymmetric reduction of a 2-oxocycloalkanecarboxylic acid ester with a bacterial strain or its processed material.

Process for producing optically active 2-hydroxycycloalkanecarboxylic

A tasty yeast extract is obtained by heating an aqueous suspension of yeast at 55.degree. to 70.degree. C., allowing the yeast cells to autolyze at pH 8 to 10, and eliminating water insoluble matter from the suspension and recovering the yeast extract.

Method for producing yeast extract

L-Glutamic acid is produced in a high yield by cultivating an L-glutamic acid-producing microorganism which requires oleic acid but does not require biotin for growth in a culture medium containing an oleic acid compound and a biotin compound of no less than 100 .mu.g/liter as biotin, with carbohydrate and acetic acid as carbon sources being maintained in a weight ratio of about 80:20 through about 40:60.

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Takasago, Japan

Yoshio Sugiyama