Kureha Kagaku Kogyo Kabushiki Kaisha

Yoshio Omura

Chikao Yoshikumi

Toshihiko Wada

Takayoshi Fujii

Fumio Hirose

Saburo Ueno

Eiichi Takahashi

Takao Ando

Kenichi Matsunaga

Noriyuki Toyoda

Tetsuya Hotta

Hiromitsu Makita

Isamu Motokawa

Mayumi Nohara

Katsuo Sakurai

Disclosed is nitrogen-containing polysaccharide substantially free of units having a molecular weight below about 5,000, said nitrogen-containing polysaccharide having been extracted from Coriolus versicolor (Fr.) Quel., substantially all polymer units having a molecular weight below about 5,000 having been removed therefrom, which exhibits antitumor and immunological activity.

Nitrogen-containing polysaccharide

A method of restoring the immune response of a patient having a lowered immune response level is provided, in which the patient is given an effective amount of certain nitrogen-containing polysaccharides derived from Coriolus versicolor (Fr.) Quel, where the polymer units having a molecular weight of below about 5,000 have been removed therefrom.

Disclosed is an agent comprising cyclodextrin as the active ingredient and a method for using such agent to promote the proliferation of intestinal bifidobacteria in animals.

Cyclodextrin and method for promoting the proliferation of intestinal

A nitrogen-containing polysaccharide, which is obtainable by extracting mycelia of a fungus belonging to the genus Coriolus of Polyporaceae of Basidiomycetes with an aqueous solvent, is effectively used in treating a bacterial infectious disease due to the strain of the pathogenic bacterial species, which has come to be resistant to the treatment with conventional antibiotics.

Pharmaceutical composition comprising a nitrogen-containing

The fungi belonging to the Coriolus genus is first extracted with water or a dilute alkaline solution and then further extracted stepwise by using alkaline solutions with gradually increased concentrations to obtain a nitrogen-containing polysaccharide having an anti-tumor activity in a high yield.

Method of producing nitrogen-containing polysaccharides

The fungi belonging to the Coriolus genus are extracted by using a dilute alkaline solution having a concentration within a certain specified range whereby the low molecular weight substances with molecular weight of less than 5,000 are obtained in there extract solution. These low molecular weight substances are separated from the extract solution to obtain a nitrogen-containing polysaccharide having excellent anti-tumor activity.

When a dikaryotic mycelium of Coriolus versicolor (Fr.) Quel. (a species of fungi belonging to the genus Coriolus of Polyporaceae) is subjected to a mechanical treatment such as grinding or shearing in a liquid medium, or when such mycelium is subjected to submerged culture while undergoing mechanical treatment, there is produced a monokaryotic mycelium which is different from the dikaryotic mycelium in morphological and physiological characteristics. The thus obtained monokaryotic mycelium is a novel product and characterized by its extremely high propagation rate as compared with the known dikaryotic mycelium. Also, the substance extracted from the culture of the mycelium has excellent physiological activities.

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Tanashi, Japan

Yoshio Omura