Nissan Chemical Industries Limited

Daicel Chemical Industries, Ltd.

Meiji Co., Ltd.

Yoshio Ohara

Mikio Suzuki

Hiroshi Kashihara

Kazutaka Arai

Nobuhide Miyachi

Yoshinobu Yanagawa

Hiroshi Iwasaki

Yasuhiro Takahashi

Hiroo Matsumoto

Kazufumi Yanagihara

Toru Yamashita

Kazuhiko Ohrai

Yukihiro Shigeta

Toru Tsukagoshi

Yasuo Takakuwa

Toyoko Iizumi

Katsuaki Miyaji

Ken-ichi Shikada

Hirokazu Ikeda

Tatsushi Murakami

Yasutaka Takada

Keisuke Ohdoi

Takashi Yotsumoto

Takeshi Naito

Tetsuya Kobayashi

Katsuhiro Kato

Hiroyasu Kanda

Yashio Takakuwa

Syuuzi Tsuchiya

Akihiro Yoshida

Akio Tanaka

Tetsuya Magarikaji

This invention relates to benzopyran derivatives of the formula (1) or the formula (2) wherein Rand Rrepresent independently of each other hydrogen atom or Calkyl group, Rrepresents hydroxyl group or Calkylcarbonyloxy group, Rrepresents hydrogen atom or Calkyl group, Rrepresents Calkyl group substituted with Caryl group or heteroaryl group, Rrepresents Calkyl group, Calkoxy group, halogen atom, nitro group, C(O)NH, C(O)NHRor C(O)NRR, or pharmaceutically acceptable salts thereof. These compounds are useful as an antiarrhythmic agent 

Substituted benzopyran derivatives against arrhythmia

This invention relates to benzopyran derivatives of the formula (I) wherein, R and R represent each independently a C alkyl group, etc, R represents a hydroxyl group, etc, R represents a hydrogen atom, etc, R represents a hydrogen atom, R represents a hydrogen atom, etc, X is absent, or represents C&boxH;O, etc, R represents a hydrogen atom, a C alkyl group, etc, R represents a hydrogen atom or a nitro group, when R represents a nitro group, Y represents a C alkylene group, &mdash;(CH ) &mdash;CR R &mdash;(CH ) &mdash; or &mdash;(CH ) &mdash;O&mdash;(CH ) &mdash;, R represents a hydrogen atom, an amino group, a C alkoxy group, a C alkylthio group, a C alkylamino group, a C alkoxycarbonylamino group, etc, or pharmaceutically acceptable salts thereof. These compounds are useful as an antiarrhythmic agent.

4-aminobenzopyran derivatives

The present invention relates a process for producing the quinoline derivative (3) via the nitrile compound (1) obtained by reacting the aldehyde compound represented by formula (2) with diethyl cyanomethylphosphonate and its intermediate (1).

Process for the preparation of quinoline derivative and intermediate therefor

The present invention provides novel pyridine type thiazolidines and their salts, expressed by the following formula (I): ##STR1##

Pyridine type thiazolidines

Process for preparing optically active mevalonolactone compounds

An optically active .beta.-aminoalkoxyborane complex of the formula (I): ##STR1## wherein R.sup.1 is C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.7 -C.sub.11 aralkyl or C.sub.6 -C.sub.10 aryl, R.sup.2 is hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.7 cycloalkyl or C.sub.7 -C.sub.11 aralkyl, or R.sup.1 and R.sup.2 together form (CH.sub.2)n wherein n is 3 or 4, and Ar is naphthyl, anthryl or phenanthryl, which may be substituted by from 1 to 3 substituents selected from the group consisting of halogen, nitro, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.7 -C.sub.11 aralkyl, C.sub.6 -C.sub.10 aryl, C.sub.1 -C.sub.6 alkoxy and styrene polymer substituents.

Optically active .beta.-aminoalkoxyborane complex

1. An optically active .beta.-aminoalkoxyborane complex of the formula (I): ##STR1## wherein R.sup.1 is C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.7 -C.sub.11 aralkyl or C.sub.6 -C.sub.10 aryl, R.sup.2 is hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.7 cycloalkyl or C.sub.7 -C.sub.11 aralkyl, or R.sub.1 and R.sup.2 together form (CH.sub.2).sub.n wherein n is 3 or 4, and Ar is naphthyl, anthryl or phenanthryl, which may be substituted by from 1 to 3 substituents selected from the group consisting of halogen, nitro, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.7 -C.sub.11 aralkyl, C.sub.6 -C.sub.10 aryl, C.sub.1 -C.sub.6 alkoxy and styrene polymer substituents.

Optically active beta-aminoalkoxyborane complex

An optically active .beta.-aminoalkoxyborane complex of the formula (I): ##STR1## wherein R.sup.1 is C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.7 -C.sub.11 aralkyl or C.sub.6 -C.sub.10 aryl, R.sup.2 is hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.7 cycloalkyl or C.sub.7 -C.sub.11 aralkyl, or R.sup.1 and R.sup.2 together form (CH.sub.2).sub.n wherein n is 3 or 4, and Ar is naphthyl, anthryl or phenanthryl, which may be substituted by from 1 to 3 substituents selected from the group consisting of halogen, nitro, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.7 -C.sub.11 aralkyl, C.sub.6 -C.sub.10 aryl, C.sub.1 -C.sub.6 alkoxy and styrene polymer substituents.

A diastereomer salt of optically active quinolinemevalonic acid of the formula ((-)I.multidot.(+)II): ##STR1##

Diastereomer salt of optically active quinolinemevalonic acid

A diastereomer salt of optically active quinolinemevalonic acid of the formula ((-)I.(+)II): ##STR1##

A compound having the formula: ##STR1## wherein R is a hydroxyl-protecting group, X is a hydrogen atom, CO.sub.2 R' (wherein R' is a hydrogen atom or an alkyl group having from 1 to 7 carbon atoms, or CO.sub.2 R' is a salt of CO.sub.2 H), or a group of the formula: ##STR2## and when X is a hydrogen atom, Y is CO.sub.2 R' (wherein R' is as defined above) or a group of the formula: ##STR3## and when X is CO.sub.2 R' or the group of the formula (i), Y is a hydrogen atom.

Optically active bicyclo carboxylic acids and their derivatives

Growing community of inventors

Funabashi, Japan

Yoshio Ohara