Dainippon Sumitomo Pharma Co., Ltd.

Yoshio Nakai

Hiroyuki Nakahira

Yohei Ikuma

Nobuhisa Fukuda

Satoshi Suetsugu

Hidenori Kimura

Kozo Yoshida

Junya Ikeda

Kiyoto Sawamura

Takashi Takada

Akira Fusano

The present invention provides a compound of formula (I): wherein Ris optionally substituted Calkyl, etc.; Ris hydrogen atom, etc.; G, G, Gand Gare (i), etc. ((i) Gis &#x2014;N(R)&#x2014;, Gis &#x2014;CO&#x2014;, Gis &#x2014;C(R)(R)&#x2014;, and Gis oxygen, etc.); Ris optionally substituted Calkyl, etc.; Rand Rare each independently optionally substituted Calkyl, etc.; Ris optionally substituted Calkyl, etc.; R, R, Rand Rare each independently a group: -A-B (A is a single bond, etc., B is hydrogen atom, etc.), etc.; n is 1, etc.; Ris Calkoxycarbonyl, etc., or a pharmaceutically acceptable salt thereof, which is useful as a renin inhibitor.

N-substituted-cyclic amino derivative

The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, being useful as a renin inhibitor. [wherein Ris halogen, etc.; Ris H, etc.; Gis &#x2014;N(R)&#x2014;, etc.; Gis &#x2014;CO&#x2014;, etc.; Gis &#x2014;C(R)(R)&#x2014;, etc.; Gis oxygen, etc.; Ris optionally substituted Calkyl, etc.; Rand Rare independently the same or different, H, etc.; Ris H, optionally substituted Calkyl, etc.; R, R, Rc and Rare independently the same or different, and a group: -A-B (said A is single bond, etc., and said B is H, etc.), etc.; and n is 1, etc.]

Bicyclic heterocyclic derivative

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Suita, Japan

Yoshio Nakai