Takeda Chemical Industries, Inc.

National Cancer Center

Yoshio Kozai

Kiminori Tomimatsu

Yumiko Shibouta

Muneo Takatani

Kohei Nishikawa

Hiroaki Nomura

Susumu Tsushima

Kaneyoshi Kato

Koichi Igarashi

Naoto Hashimoto

Masaaki Terada

Teruhiko Yoshida

Hiromi Sakamoto

Takatani Muneo

A deletion type mutein of heparin-binding secretory transforming factor (hst-1) possesses excellent cell growth promoting activity and is stable. The present mutein can therefore be used as a therapeutic medicine such as a healing promoter for burns, wounds, surgical injuries etc.

Deletion muteins of hst-1

A calmodulin inhibitory composition containing a compound of the formula (I): ##STR1## as well as an angiogenesis inhibitory composition containing a compound of the formula (1): ##STR2## are disclosed.

Imidazopyridine derivatives and their use

A compound of the formula: ##STR1## wherein, R.sup.1 and R.sup.2 are the same or different/representing methyl or methoxy groups, or form --CH.dbd.CH--CH.dbd.CH-- by binding to each other; R.sup.3 is an aromatic group or a heterocyclic group which may be substituted; and n is an integer of 2 to 8, shows inhibitory effect of cell proliferation and is useful as cell proliferation inhibitor.

Cell proliferation inhibitor

Imidazopyridine derivatives and their pharmaceutical use

Novel lipid derivatives of the formula ##STR1## [wherein R.sup.1 is alkyl or alkylcarbamoyl; R.sup.2 is hydrogen, hydroxy which may be substituted, amino which may be substituted or cyclic amino; R.sup.3 is a chemical binding or alkylene which may be substituted; R.sup.4 is hydrogen, alkyl or aralkyl; X and Y are independently O, S or an imino group which may be substituted, and when Y is an imino group, Y, together with the imino group represented by X or R.sup.4, may form a ring; and Z is imino or a nitrogen-containing heterocyclic ring which may be substituted] and salts thereof have inhibiting activity on platelet activating factor and are useful as a preventive or therapeutic agent for a variety of circulatory diseases and allergic disorders and also as an antineoplastic agent.

Lipid derivatives, their production and use

Growing community of inventors

Toyonaka, Japan

Yoshio Kozai