Sumitomo Pharmaceuticals Company Limited

Yoshio Ito

Shiro Terashima

Tamejiro Hiyama

Kunikazu Sakai

Yoshikazu Kimura

Makoto Sunagawa

Akira Sasaki

Katsumi Tamoto

Takeo Kawabata

A compound of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each a hydrogen atom, a lower alkyl group, an ar(lower)alkyl group or an aryl group, or R.sub.1 and R.sub.2 may be combined together to form a lower alkylene group and/or R.sub.3 and R.sub.4 are combined together to form a lower alkylene group, or R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be combined together to form an o-phenylene group, X is a halogen atom and Y is an oxygen atom or a nitrogen atom substituted with lower alkyl or aryl, which is useful as an intermediate in the synthesis of 1.beta.-methylcarbapenem compounds valuable as antibiotics.

Heterocyclic compounds and their production

An amino acid derivative of the formula: ##STR1## wherein R.sup.1 is a protective group for hydroxyl, which is useful as an intermediate for production of antimicrobial agent.

Amino acid derivatives, and their production

Growing community of inventors

Sagamihara, Japan

Yoshio Ito