Tokyo University of Pharmacy & Life Sciences

The University of Tokyo

National Cerebral and Cardiovascular Center

Kyoto Pharmaceutical University

Kokusan Chemical Co., Ltd.

Yoshio Hayashi

Akihiro Taguchi

Kentaro Takayama

Kenji Kangawa

Ryoichi Matsuda

Akira Yamamoto

Masataka Shiozuka

Mikiya Miyazato

Yoichi Negishi

Kenji Mori

Toshiyasu Sakane

Fumika Yakushiji

Kentaro Fukumoto

Yuri Yamazaki

Provided is a peptide having a short chain length, for example, having the number of amino acid residues of 20 or less and having a high myostatin inhibitory activity. The present invention is a peptide comprising an amino acid sequence represented by Formula (1) in the specification and having the number of amino acid residues of 20 or less.

Peptide or pharmaceutically acceptable salt thereof, or prodrug thereof

The present invention provides a means capable of selectively introducing a disulfide bond with respect to two free thiol groups located in a molecule of an organic compound such as a peptide, or the like, in a short time by a simple treatment and also by a chemically stable method. A nitrogen-containing compound represented by Chemical Formula 1 below or a salt thereof:  The symbols shown in Chemical Formula 1 are the same as defined in the specification.

Selective disulfidation reagent using nitrogen-containing compound and method for producing disulfide-containing compound

To provide a peptide that selectively activates type 2 neuromedin U receptor and is chemically stable under physiological conditions. A peptide represented by Formula (1) described in the specification.

[Problem] Provision of a novel compound having read-through activity and a drug for the treatment of nonsense mutation-type disease containing this compound. [Solution] A compound represented by the following general formula (1): and a pharmaceutical composition containing this compound.

Compound having read-through activity

Growing community of inventors

Tokyo, Japan

Yoshio Hayashi