Nakano Vinegar Co., Ltd.

Nikano Vinegar, Co., Ltd.

Yoshinori Tsukamoto

Mikio Yamada

Masahiro Mizuno

Yoshiya Kawamura

Noriko Takahashi

Koki Yamada

Koichi Sato

Masahiro Fujimori

Masashi Mizokami

Chizu Ishida

Hiroaki Nakagawa

Hiroyuki Ohsuga

Tetsuya Kibe

Kazuo Yoshioka

The present invention relates to a novel clinical examination method which comprises analyzing the alteration in the amount of a specific component in oligosaccharides of immunogloblin G. Human diseases such as liver diseases, malignant hypertension, immunogloblin A-nephropathy, pediatric disorders, etc., are examined in terms of the alteration in bisecting N-acetylglucosamine-containing oligosaccharides in immunogloblin G from collected humor. The present invention provides highly accurate information in a manner applicable to practical operation for examination of liver diseases, allergic diseases, malignant hypertension, immunogloblin A nephropathy, pediatric disorders, as well as aging-dependent variations and the therapeutic effect of interferon.

Method for clinical examination based on the structures of immunoglobin

A method and apparatus for producing vinegar by acetic acid fermentation utilizing an automatic alcohol analyzer for measurement of alcohol concentration in a fermenting broth, a feeding apparatus for feeding alcohol solution as raw material to the fermenting broth, and a control computer controllably coupled to the alcohol analyzer and to the feeding apparatus. The alcohol concentration in the fermenting broth is periodically measured by the automatic alcohol analyzer by a direction from the control computer at given intervals over a plurality of cycles of measurement; the control computer calculates a feed rate of alcohol solution as raw material to the fermenting broth so as to control the alcohol concentration in the fermenting broth at a desirable concentration on the basis of a difference between a measured alcohol concentration in the fermenting broth and a desirable alcohol concentration and the alcohol consumption rate calculated during each of the cycles by the control computer; and then the feeding apparatus is operated to control the feed rate of the alcohol solution responsive to a control signal generated by the control computer as a result of the aforementioned calculations, to thereby controllably feed alcohol solution as raw material to the fermenting broth.

Apparatus for automatically controlling the feed rate of alcohol

A method for measuring the alcohol concentration of an acetic acid fermentation broth which comprises (a) forming a sample gas containing volatile components present in the acetic acid fermentation broth, the volatile componentscomprising alcohol and acetic acid; (b) passing the sample gas through an absorption column packed with a material which binds acetic acid whereby the acetic acid is absorbed on the material; (c) passing the sample gas which has passed through the absorption column to a gas sensor for measuring the alcohol content of the gas by outputting an electrical signal which correlates to the alcohol content of the sample gas; and (d) determining the alcohol content of the sample gas in response to the electrical output signal from the gas sensor. The invention also provides a method of forming the sample gas by passing a sample of the fermentation broth through a water-repellent gas permeable tube mounted in a hollow cell and passing a carrier gas through the hollow cell whereby volatile components from the fermentation broth inside of the tube diffuse through the gas permeable tube wall and are intermixed with the carrier gas to form the sample gas containing the volatile components.

Method for a measurement of alcohol concentration in acetic acid

A method and apparatus for producing vinegar by acetic acid fermentation utilizing an automatic alcohol analyzer for measurement of alcohol concentration in a fermenting broth, a feeding apparatus for feeding alcohol solution as raw material to the fermenting broth, and a control computer controllably coupled to the alcohol analyzer and to the feeding apparatus. The alcohol concentration in the fermenting broth is periodically measured by the automatic alcohol analyzer by a direction from the control computer at given intervals over a plurality of cycles of measurement; the control computer calculates a feed rate of alcohol solution as raw material to the fermenting broth so as to control the alcohol concentration in the fermenting broth at a desirable concentration on the basis of a difference between a measured alcohol concentration in the fermenting broth and a desirable alcohol concentration and the alcohol consumption rate calculated during each of the cycles by the control computer; and then the feeding apparatus is operated to control the feed rate of the alcohol solution responsive to a control signal generated by the control computer as a result of the aforementioned calculations, to thereby controllably feed alcohol solution as raw material to the fermenting broth. Alternatively, the control computer calculates a feed rate of alcohol solution as raw material to the fermenting broth so as to control the alcohol concentration in the fermenting broth at a predetermined desirable concentration according to acetic acid concentration on the basis of increasing rate of acetic acid concentration, acetic acid concentration and total concentration in the fermenting broth which are calculated by the control computer every cycle over a number of cycles at given intervals, the acetic acid concentration and total concentration being determined at a set point in an appropriate period during fermentation.

Method for automatically controlling feed rate of alcohol solution as

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Handa, Japan

Yoshinori Tsukamoto