Kao Corporation

Yoshinori Takema

Genji Imokawa

Tsutomu Fujimura

Yukihiro Ohashi

Minoru Nagai

Shigeru Moriwaki

Yasuto Suzuki

Naoko Tsuji

Ayumi Ogawa

Akira Kawamata

Yukihiro Yada

Kazuhiko Higuchi

Taketoshi Fujimori

Toshiya Ono

Toshiyuki Suzuki

Yoshinori Nishizawa

Kazuya Otsuji

Akira Yamamuro

Kikuhiko Okamoto

Atsushi Ohuchi

Satoshi Takano

Noriko Ito

Kazumi Saito

Mikako Watanabe

Hakaru Inaoka

Satoshi Kanazawa

Yasuki Honda

Yukio Sugimura

Yukiko Sakaino

Hiroyuki Ohsu

Noriko Okamura

Koichi Nakamura

Rikio Tsushima

Hiroshi Kusuoku

Yoshinao Kono

Masakazu Yamaguchi

Kazue Tsukahara

Eiichi Nishizawa

Yutaka Yasuda

Mitsuru Sugiyama

Disclosed herein are a method of inhibiting hair growth, which comprises administering an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor, and use of an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor for the preparation of a hair-growth inhibitor.

Method of inhibiting hair growth

Wrinkling modifiers

The invention relates to wrinkling modifiers and anti-aging cosmetic compositions which each comprise a guanidine derivative represented by the following general formula (1):

Method of modifying wrinkles using guanidine derivatives

The present invention provides a skin external preparation comprising a compound of the formula (1), (2), (3) or (4).

Skin external preparation

The present invention provides a skin external preparation comprising a compound of the formula (1), (2), (3) or (4). ##STR1## wherein X represents COOH, etc., Z represents CONH.sub.2, etc. and R.sup.1 and R.sup.7 individually represent a hydrogen atom, etc. The above-described compound has excellent effects, for example, for preventing or alleviating skin aging or inhibiting hair growth.

A wrinkle-care product, an aging-preventive cosmetic and a skin cosmetic each comprising a guanidine derivative of formula (I) or an acid addition salt thereof: ##STR1## wherein R1 represents a hydrogen atom, a lower alkyl group or --(AO).sub.m --(BO).sub.n --D--E �wherein A and B may be the same or different and each represents an alkylene group having 2 to 8 carbon atoms; D represents a binding hand, --CO--, or an unsubstituted or substituted alkylene group having 1 to 6 carbon atoms; E represents a hydrogen atom, a lower alkyl group, an aralkyl group or an unsubstituted or substituted aryl group; m is a number of from 1 to 6; and n is a number of from 0 to 6!; k is a number of from 1 to 10; and G represents a hydrogen atom, a hydroxyl group, a carboxyl group, a sulfonate group or a phosphate group. These products are excellent in the effects of inhibiting wrinkling and smoothing wrinkles without damaging the physiological conditions of the skin.

Wrinkle-care product

Amine derivative and dermatologic preparation containing the same

Singlet oxygen quenchers containing as an active component a compound represented by the following formula or (2): ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.10 and n are as described herein, and external compositions containing these compounds are provided for the prevention and treatment of various forms of damage to living bodies caused by singlet oxygen, and are thus quite useful as antiinflammation agents, anti-aging agents, agents preventing darkening of the skin, agents preventing protein denaturation, inhibitors against formation of sunburn cells, agents preventing lipid peroxidation, agents preventing DNA damage, and particularly in the fields of medicines and cosmetics as external compositions for the skin.

Singlet oxygen quenchers and external compositions containing the same

A composition for external skin care comprising an amine derivative represented by the following formula (1), ##STR1## wherein R.sup.1 is a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 4-40 carbon atoms, and R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are individually a hydrogen atom or a hydrocarbon group having 1-10 carbon atoms, which may be substituted or unsubstituted by 1 or more hydroxy groups; or an acid addition salt thereof, in an amount from 0.0001 to less than 0.1% by weight; and a method of curing wrinkles and keratinization of the skin characterized by applying said amine derivative or its salt to the skin.

Composition for external skin care

A novel acidic heteropolysaccharide which comprises as its structural units arabinose, mannose, galactose, glucuronic acid, and xylose, at a specific ratio. The polysaccharide can be prepared by culturing a callus induced from a plant belonging to the genus Polianthes L. in a culture medium containing plant hormones. The polysaccharide can be used as a component of agents for external application and detergents, and provides good moisturizing effects and a smooth, satisfying feeling upon use. When formulated in detergents, they produce remarkable improvement in a clean, rich feeling upon use.

Detergent composition containing polianthes L-derived acidic

Polysaccharide and process for preparing the same

A film-forming cosmetic composition useful as a facial pack, nail enamel, eye liner etc., which comprises a copolymer of vinyl alcohol and alkyl vinyl ether, being referred to simply as PVA/AVE, consisting of 98 to 80 mole % of vinyl alcohol monomer units and 2 to 20 mole % of linear or branched alkyl vinyl monomer units having from 1 to 6 carbon atoms. The molar ratio of the vinyl alcohol monomer units to the alkyl vinyl ether monomer units is in the range of from 95/5 to 85/15. The PVA/AVE according to the invention has no acetic groups with ester bonds in a molecule. Instead, there are alkyl or alkenyl groups having ether bonds which serve for steric hindrance for preventing gelation of an aqueous solution of such copolymer. From this reason, the PVA/AVE does not undergo any hydrolysis as time passes and is thus excellent in storage stability.

Cosmetic composition

Growing community of inventors

Tochigi, Japan

Yoshinori Takema