Ss Pharmaceutical Co., Ltd.

Nippon Shinyaku Company, Ltd.

Ssp Co. Ltd

Yoshinori Takahashi

Hiroyuki Mizuno

Susumu Sato

Haruyoshi Honda

Terumitsu Kaihoh

Tomomi Okada

Hideaki Matsuda

Fujiko Konno

Masago Ishikawa

Teruo Komoto

Koichi Takahashi

Susumo Sato

A preventive and/or therapeutic agent for inflammatory respiratory tract diseases containing, as an active ingredient, a steroid derivative represented by the following formula (1): (wherein R represents a hydrogen atom, a halogen atom, a hydroxy group, or &#x2014;OCOR(wherein Rrepresents a linear or branched alkyl group which may be substituted by a halogen atom or a cycloalkyl group; a cycloalkyl group; or an aryl group)). These compounds can continuously suppress respiratory tract inflammation and respiratory tract hyperreaction and show a high site selectivity and little systemic effect when administered directly to the respiratory tract. By virtue of these characteristics, these compounds are remarkably useful in clinical medicine as highly safe preventive and/or therapeutic agents for inflammatory respiratory tract diseases which can be administered for a long period of time.

Preventives/remedies for inflammatory airway diseases

Disclosed herein is a substituted piperidine derivative represented by the following general formula (1):

Substituted piperidine derivative for treating urinary disturbance

Described is an arylacetic amide derivative represented by the following formula (1): ##STR1## wherein R.sup.1 represents an aryl group or the like, R.sup.2 and R.sup.3 each independently represents an alkyl group, a cycloalkyl group or the like, and R.sup.4 represents an aralkyl group, an alkyl group or the like; or salt thereof. The compound according to the present invention has both excellent anticholinergic action and calcium antagonism and at the same time has high selectivity to bladder, so that it is useful as a preventive or remedy for urinary disorders.

Arylacetic amide derivative or salt thereof, and pharmaceutical

Disclosed herein is a substituted piperidine derivative represented by the following general formula (1): ##STR1## wherein R.sup.1 means an aryl or heteroaryl group which may have at least one substituent, R.sup.2 denotes an alkyl, alkenyl or aralkyl group, R.sup.3 stands for a hydrogen atom or an alkyl group, and R.sup.4 is a hydrogen atom, an alkyl group, or an aryl, heteroaryl, aralkyl, aralkenyl or heteroaralkyl group which may have at least one substituent, or a salt thereof. A medicine including this compound is also disclosed. The compound has excellent anticholinergic effect and calcium antagonism and inhibits reflex bladder contraction and is hence useful for prophylaxis of and treatment for a urinary disturbance such as pollakiuria.

Substituted piperidine derivative and medicine comprising the same

Growing community of inventors

Tomisato-machi, Japan

Yoshinori Takahashi