Kissei Pharmaceutical Co., Ltd.

Yoshinori Nonaka

Norihiko Kikuchi

Kazuya Tatani

Takashi Miyagi

Masayuki Isaji

Kazuo Shimizu

Hiromu Harada

Masahiro Hiratochi

Hidetoshi Isawa

Den-ichi Momose

Yukihiko Hotei

Yu Kuramochi

Koji Kamata

Yasuo Takehana

Humiyasu Satoh

Hiroshi Kusama

Mitsuhiro Ichihara

Hideki Hujikura

Masaaki Satoh

Nobuko Yanagi

The present invention provides an 8-modified purinenucleoside derivative which is useful for diseases associated with an abnormality of plasma uric acid level. An 8-modified purinenucleoside derivative represented by the following formula (I), a prodrug thereof or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof, is useful for the prevention or treatment of gout, hyperuricemia, urinary lithiasis, hyperuricemic nephropathy or the like. In the formula, n is 1 or 2; Ris a hydrogen atom or a hydroxyl group; Ris a hydrogen atom, a hydroxyl group, a thiol group, an amino group or a chlorine atom; ring J represents an optionally substituted 2-naphthyl group, or a group represented by the following general formula (II) wherein Y represents a single bond or a connecting group; ring Z represents an optionally substituted aryl group or heteroaryl group or the like; and Rto R, Pand Q represents a halogen atom, a cyano group or the like. 

Purine nucleoside derivative modified in 8-position and medical use thereof

The present invention provides benzimidazole derivatives represented by the following formula (I) or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exert an inhibitory activity on sodium-dependent nucleoside transporter 2 and are useful for a disease associated with an abnormality of plasma uric acid level. The compounds of the present invention are useful for the prevention or treatment of gout, hyperuricemia, urinary lithiasis, hyperuricemic nephropathy or the like. In the formula, n is 1 or 2; Rand Rare H, a halogen atom, cyano group, optionally substituted alkyl group, optionally substituted aryl group or the like; Ris H, a halogen atom, optionally substituted alkyl group or the like; Rand Rare H, a halogen atom, OH or the like; and Rand Rare H or OH: Ris F or OH. 

Benzimidazole derivatives and medical uses thereof

Polyphenylene ether resin

1-(2-benzimidazolyl)-1,5-diazacyclooctane compounds

Growing community of inventors

Nagano, Japan

Yoshinori Nonaka