Kao Corporation

Yoshinori Nishizawa

Akira Kiyomine

Hiroaki Saito

Yoshiya Sugai

Masahide Hoshino

Toru Yoshihara

Jiro Kawase

Hidetoshi Tagami

Tadashi Tamura

Yasushi Katayama

Hidenori Yorozu

Bernd Nocker

Mituru Sugiyama

Satoshi Kanazawa

Masahiko Ogawa

Yukihiro Ohashi

Genji Imokawa

Koichi Nakamura

Shigeru Moriwaki

Hirotaka Sato

Yoshinori Takema

Yasuto Suzuki

Naoko Tsuji

Atsushi Ohuchi

Shinobu Nagase

Mitsuyuki Hotta

Shinobu Mori

Akiyo Kameyama

Mikako Watanabe

Yutaka Takagi

Susumu Ichinose

Hideshi Kidena

Hitoshi Sakaguchi

Kenichi Morita

Yukihiro Kondo

Hiroyuki Suzuki

Katsutoshi Ara

Hiroshi Kusuoku

Burkhard Rose

Taketoshi Fujimori

Norihiro Tanaka

Yuji Ichii

Tsutomu Muraoka

Shunichi Akiba

Hakaru Inaoka

Mio Ishita

Michio Tanaka

Masatomo Ando

Ken-ichi Matsunaga

To provide a method for performing a cross-coupling reaction of a Grignard compound with an alkyl halide simply, efficiently and in high yield, a method for obtaining a &#x3c9;-bromo long chain carboxylic acid simply and efficiently using an easily obtainable raw material and a method for producing a useful branched fatty acid simply and efficiently  [R: an alkyl group having 1 to 15 carbon atoms, R: an alkyl group having 1 to 30 carbon atoms with a carboxyl group and X and X': a halogen atom]  [n: an integer of 9 to 17]  [n: an integer of 9 to 17, R: a branched alkyl group having 3 to 8 carbon atoms and X: a halogen atom].

Method for producing cross-coupling compound

The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following formula (1): (wherein, Rand Rare the same or different and each represents a Chydrocarbon group, Rand Rare the same or different and each represents a divalent Chydrocarbon group, Rs are the same or different and each represents a divalent Chydrocarbon group and n stands for 1 to 100). The composition for external application, humectant and skin barrier function reinforcing agent basically improve the water retaining ability and barrier functions of the horny layer, are excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.

Composition for external application

The present invention relates to a dermatologic preparation containing a diamide derivative represented by the following formula (1): (wherein, Rrepresents a linear or branched hydrocarbon group having 1 to 22 carbon atoms which may be substituted by one or more hydroxy and/or alkoxy groups, Rrepresents a linear or branched divalent hydrocarbon group having 1 to 12 carbon atoms, and Rrepresents a linear or branched divalent hydrocarbon group having 1 to 42 carbon atoms). This diamide derivative (1) is capable of fundamentally improving the water retention capacity and barrier functions of the horny layer, is excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.

Dermatological preparations

The invention contemplates drugs useful for maintenance or promotion at sites of regenerating nerves and for prevention or treatment of pathological conditions caused by denaturation or cell damage in the nervous system. Thus, the invention provides an apolipoprotein D degradation inhibitor containing lauric acid or oleic acid as an active ingredient.

Apolipoprotein D degradation inhibitor

External preparation compositions

A bathing preparation comprising an alkyl phthalide and/or an alkoxy phthalide and/or an alkylidene phthalide optionally together with carbon dioxide gas or a material capable of generating carbon dioxide gas and an extract of a plant belonging to the family Umbelliferae is disclosed. This bathing preparation has excellent effects of warming, retaining the warmth and accelerating blood circulation.

Bathing preparation

The present invention provides a skin external preparation comprising a compound of the formula (1), (2), (3) or (4).

Skin external preparation

The present invention provides a skin external preparation comprising a compound of the formula (1), (2), (3) or (4). ##STR1## wherein X represents COOH, etc., Z represents CONH.sub.2, etc. and R.sup.1 and R.sup.7 individually represent a hydrogen atom, etc. The above-described compound has excellent effects, for example, for preventing or alleviating skin aging or inhibiting hair growth.

The present invention relates to flavanonol derivatives represented by formula (1): ##STR1## (wherein R.sup.1 represents an alkyl group, and each of R.sup.2 and R.sup.3 represents a hydrogen atom, an alkyl group which may have a substituent, an alkoxyl group which may have a substituent, a hydroxyl group, a cyano group, or a halogen atom), as well as to hair-nourishing and hair-growing compositions containing the derivatives. The compounds accelerate differentiation and proliferation of hair matrix cells, thereby exhibiting remarkable hair-nourishing and hair-growing effects.

Flavanonol derivatives and hair-nourishing, hair-growing compositions

The object of the invention is a new isomer mixture of 3-hydroxybutyl monothioglycollate and 3-hydroxy-1-methyl propyl monothioglycollate in a weight proportion of about 1.5:1 to 4:1, preferably about 2:1 to about 3:1, comprising less than 5%, preferably less than 2% by wt., of 1,3-butanediol thioglycollate, and its use as the sole or main reducing agent in compositions for permanent waving of human hair. The compositions have reduced smell, good waving properties and an extremely low sensitizing potential on human skin.

1,3-butanediol thioglycollate isomer mixture and permanent waving

The object of the invention is a composition for permanent waving of human hair comprising, as sole or main reducing agent one or several polyglycol monothioglycollates or lactates of the general formula ##STR1## wherein R denotes a hydrogen atom or a methyl group, X represents an ethoxy or propoxy group, and n is a number from 2 to 5. These compositions have a low characteristic smell, good waving properties, and an extremely low skin sensitizing potential.

Composition for permanent waving of human hair

Flavanonol derivatives and hair-nourishing, hair growing compositions

The present invention provides a lipolysis acceleration method which comprises orally administering a thistle-series or pepper-family plant, or an extract thereof; or dermatologically applying it by local administration or as a bath medicine composition. According to the method of the present invention, marked lipolysis acceleration effects can be obtained. It exhibits excellent effects for the control, prevention and improvement of obesity.

Lipolysis acceleration method

Growing community of inventors

Haga-gun, Japan

Yoshinori Nishizawa