Other

Yamanouchi Pharmaceutical Company Ltd.

Yoshinori Masuda

Takao Mizumoto

Atsushi Kajiyama

Masahiro Yanagisawa

Janaki Ram Nyshadham

Yuuki Takaishi

Muneo Fukui

The present invention relates to a quick-disintegrating tablet in the buccal cavity comprising a drug, a diluent, and a saccharide with a relatively lower melting point than the drug and the diluent, which is obtained by uniformly mixing the saccharide with a low melting point in the tablet so that a bridge will be formed between said drug and/or said diluent particles by the product of melting and then solidification of this saccharide with a low melting point. Moreover, the present invention relates to a method of manufacturing a quick-disintegrating tablet in the buccal cavity comprising a drug, a diluent and a saccharide with a relatively lower melting point than the drug and the diluent, which comprises (a) the process whereby tablet starting materials including a drug, a diluent, and a saccharide with a relatively lower melting point than the drug and the diluent are molded under the low pressure necessary for retaining the shape of a tablet, (b) the process whereby the molded product obtained in process (a) is heated to at least the temperature at which this saccharide with a low melting point will melt, and (c) the process whereby the molded product obtained in process (b) is cooled to at least the temperature at which the molten saccharide with a low melting point solidifies. The present invention presents a quick-disintegrating tablet in the buccal cavity that can be used for practical purposes in that it has almost the same properties as conventional oral pharmaceutical tablets, that is, it has sufficient tablet strength that it can be used with automatic unit dosing machines, and it is produced by conventional tableting machines, and a manufacturing method thereof. Moreover, the present invention presents a quick-disintegrating tablet in the buccal cavity which, in comparison to conventional quick-disintegrating tablets in the buccal cavity, has increased tablet strength and an improved friability without prolonging the disintegration time in the buccal cavity, and a manufacturing method thereof.

Quick-disintegrating tablet in buccal cavity and manufacturing method thereof

Technical field

Tablets quickly disintegrating in the oral cavity and process for producing the same

Intrabuccally dissolving compressed moldings comprising a saccharide having low moldability having been granulated with a saccharide having high moldability. The moldings of the present invention show quick disintegration and dissolution in the buccal cavity and have an adequate hardness.

Intrabuccally dissolving compressed moldings and production process

Growing community of inventors

Shizuoka, Japan

Yoshinori Masuda