Kuraray Co., Ltd.

Meiji Dairies Corporation

Yoshinori Asakawa

Masashi Yamada

Masayuki Uchida

Hiroto Suzuki

Yukie Suma

Sachiko Okabe

Natsuko Murata

The present invention provides a TNF-&#x3b1; production inhibitor containing a kavalactone as an active ingredient, which inhibitor has high safety, exerts an excellent effect of inhibiting TNF-&#x3b1; production, and is useful as a drug or an animal drug for preventing, ameliorating, or treating diseases such as cachexia attributed to cancer or infectious diseases, chronic rheumatoid arthritis, inflammatory diseases, osteoarthritis, systemic lupus erythematosus (SLE), rejection during bone marrow transplantation, multiple organ failure, AIDS, meningitis, hepatitis, and type-II diabetes. The present invention also provides a preventive, ameliorating, or therapeutic agent for diseases caused by abnormal production of TNF-&#x3b1;, the agent containing a kavalactone as an active ingredient.

TNF-&#x3b1; production inhibitor comprising kavalactone as an active ingredient

The present invention provides a TNF-&agr; production inhibitor containing a kavalactone as an active ingredient, which inhibitor has high safety, exerts an excellent effect of inhibiting TNF-&agr; production, and is useful as a drug or an animal drug for preventing, ameliorating, or treating diseases such as cachexia attributed to cancer or infectious diseases, chronic rheumatoid arthritis, inflammatory diseases, osteoarthritis, systemic lupus erythematosus (SLE), rejection during bone marrow transplantation, multiple organ failure, AIDS, meningitis, hepatitis, and type-II diabetes. The present invention also provides a preventive, ameliorating, or therapeutic agent for diseases caused by abnormal production of TNF-&agr;, the agent containing a kavalactone as an active ingredient.

TNF-&agr; production inhibitor comprising kavalactone as an active ingredient

There is provided an aroma composition containing 1,5,8,8-tetramethylbicyclo[8.1.0]undec-5-en-2-one. This sesquiterpene ketone has an aroma reminiscent of a variety of odors based on the strong powdery, woody note and furthermore has high diffusivity and retentivity and accords well with a number of perfume, fragrance and flavor materials.

Aroma composition

There is provided an aroma composition containing a sesquiterpene alcohol having the hexahydroindane skeleton. Such sesquiterpene alcohol has a fantastic aroma reminiscent of a variety of odors based on the woody note and powdery green note and furthermore has high diffusivity and retentivity and accords well with a number of perfume and fragrance materials and flavor materials.

Growing community of inventors

Tokushima, Japan

Yoshinori Asakawa