Hoffmann-la Roche Inc.

Shionogi Company Limited

Matsushita Electric Industrial Co., Ltd.

F. Hoffmann-la Roche Ag

Yoshinori Ando

Takao Shishido

Steffen Wildum

Takeshi Noshi

Klaus Kuhlbusch

Barry Clinch

Kaoru Baba

Takahiro Noda

Jan Michal Nebesky

Annabelle Lemenuel

Aeron C Hurt

Wendy S Barclay

Ryu Yoshida

Leo Yi Yang Lee

Jean-Eric Charoin

Toshiki Matsukawa

Yasuharu Kinoshita

Shoji Hoshitoku

Masaharu Takahashi

Annabelle Lemenuel-Diot

Michael J Nebesky

The present invention relates to a method for preventing transmission of influenza, wherein said method comprises administering an effective amount of a compound to a patient having an influenza virus infection, herein referred to as 'index patient', wherein the compound has one of the formulae (I) and (II), or its pharmaceutically acceptable salt. The compound to be used in the present invention reduces infectivity of the influenza virus of the index patient, and therefore, reduces the risk of the index patient to trigger an influenza epidemic or an influenza pandemic as compared to a control patient. Therefore, one aspect of the present invention relates to a method for preventing an influenza epidemic or an influenza pandemic, wherein the method comprises administering an effective amount of a compound to patients having an influenza virus infection (index patients), wherein the compound is administered to at least 10% of all influenza infected persons of a city's or country's population, and wherein the compound has one of the formulae (I) and (II), or is a pharmaceutically acceptable salt thereof.

Compound and method for the prevention of transmission of influenza virus

A multiple chip resistor is manufactured in the following method. First electrode layers are formed on a first surface of a substrate. Resistor elements electrically connected to the first electrode layers, respectively, are formed on the first surface of the substrate. Slits are formed in the substrate for separating the first electrode layers. Edge electrodes connected to the first electrode layers at the edges of the slits, respectively, are formed on respective edges at the slits of the substrate. The substrate is divided at the slits into strip substrates. Portions of the edge electrodes are removed for electrically isolating the resistor elements from each other. The method provides the edge electrodes on each strip substrate with an improved dimensional accuracy, hence allowing the edge electrodes to be isolated electrically from each other. Consequently, the multiple chip resistor is prevented from being mounted defectively when the resistor is surface-mounted.

Method for manufacturing chip resistor

Growing community of inventors

Osaka, Japan

Yoshinori Ando