Ajinomoto Co., Ltd.

Yoshinobu Takino

Yusuke Amino

Fumie Okura

Keiji Iwasaki

Shinji Kuroda

Megumi Kaneko

Yuzuru Eto

Kazutami Sakamoto

Koichiro Sagawa

Satoru Ohashi

Eiji Shiojiri

Chiori Ijichi

Sachise Karakawa

Maki Shimada

Hiromi Chujou

Eri Ikegami

Cysteine compounds represented by the following formula wherein each symbol is as defined in the specification, and salts thereof, are superior in stability, have less odor, exhibit an eumelanin production suppressive effect, and are useful as cosmetic agents.

Cysteine derivative

A topically applied circulation enhancing agent suited for application over the entire body which has good transdermal absorptivity and causes little irritation is provided. A topically applied circulation enhancing agent is provided which contains a fatty acid ester denoted by general formula (1): 

Topically applied circulation enhancing agent and skin and hair cosmetic and bath agent containing the same

Whitening cosmetic

Compound represented by formula (I): wherein the symbols are as defined in the description, and salts thereof, are useful as skin whitening agents.

Amide derivative and whitening agent

A compound represented by the following formula (I') wherein Xis a methylene group, an ethylene group, a trimethylene group or a vinylene group, Xis a divalent group represented by the following formula A or B, Y is an ethylene group or a vinylene group, m and n are each an integer of 0 to 7, which satisfy m+n=0 to 8, R1 and R2 are each independently a hydrogen atom, a methyl group or an ethyl group, provided that when Xis a methylene group, then Xis not a divalent group represented by the formula A, and when Xis a vinylene group, then Xis not a divalent group represented by the formula A. The compound is a stable capsinoid derivative, and is useful as an active ingredient of an external blood circulation enhancer or a cosmetic composition, a pharmaceutical composition, or a food composition.

Ester derivative and use thereof

The present invention provides a hair growth agent having novel action mechanism and a hair growth composition containing the agent. Specifically, the present invention provides a novel hair growth composition containing one or more kinds of epsilon-N-(gamma-glutamyl)lysine or a salt thereof.

Hair growth composition

The present invention relates to a pharmaceutical composition, a food composition or a cosmetic composition, containing one or more kinds of a compound represented by the following formula (I') wherein R1 is a hydrogen atom, a hydroxyl group, a methoxy group or an ethoxy group, R2 is a hydroxyl group, a methoxy group or an acetoxy group, or R1 and R2 in combination optionally form a methylenedioxy group,R is represented by the following formula wherein Y is an ethylene group or a vinylene group, m and n are each an integer of 0 to 7, which satisfy m+n=2 to 8, and R3 and R4 are each independently a hydrogen atom, a methyl group or an ethyl group,provided that,(1) when R1 is a methoxy group, then R2 is not a hydroxyl group; and(2) when R1 is a hydroxyl group, then R2 is not a hydroxyl group and an acetoxy group. According to the present invention, a stable capsinoid derivative is provided, and a pharmaceutical composition, a food composition, a cosmetic composition and the like containing the derivative as an active ingredient can be provided.

Substituted benzyl ester derivative and use thereof

In the present specification is disclosed a melanocyte-stimulating hormone inhibitory composition which comprises, as the active ingredient, a di- or tripeptide derivative having a certain naphthyl group or the salts thereof, or a melanocyte-stimulating hormone inhibitory compound having a 50% inhibitory concentration of cAMP production (IC50) of 100 nM or less, which composition can prevent pigmentation, or can prevent, improve or recover from immune abnormality or immunodeficiency, or regulate body weight by appetite control, and also can be used as cosmetics or external preparations for the skin, and in addition, can be produced easily, and are excellent in the stability during storage.

Growing community of inventors

Kawasaki, Japan

Yoshinobu Takino