Osaka University

Fujita Health University

Sysmex Corporation

Medical Biological Laboratories Co., Ltd.

Osaka Prefectural Government

Yoshinobu Okuno

Yoshikazu Kurosawa

Yoshitaka Iba

Kazuyoshi Ikuta

Motoki Kuhara

Ritsuko Koketsu

Shoji Ideno

Nobuko Ohshima

Masatoshi Momota

Masatoshi Oshita

Mikihiro Yunoki

Hiroshi Nishimura

Kazuo Takahashi

Kimiyasu Shiraki

Takeshi Imoarai

Motohide Takahashi

Noriyuki Saito

Yasushi Akahori

Tomokuni Taniguchi

Kazuhiko Morino

Midori Shinohara

Provided is an anti-influenza virus antibody that exhibits neutralizing activity beyond the barrier of the two groups of influenza viruses categorized according to the conservativeness of hemagglutinin amino acids, a method of producing the same, and a test method for determining whether the subject carries the neutralizing antibody.

Influenza virus-neutralizing antibody and screening method therefor

Provided is a human antibody having a neutralization activity against a human influenza virus. More specifically, provided is a human antibody which recognizes a highly conserved region in a human influenza A virus subtype H3N2 or a human influenza B virus and has a neutralization activity against the virus. The human antibody is a human anti-human influenza virus antibody, which has a neutralization activity against a human influenza A virus subtype H3N2 and binds to a hemagglutinin HA1 region of the human influenza A virus subtype H3N2, or which has a neutralization activity against a human influenza B virus, and includes, as a base sequence of a DNA encoding a variable region of the antibody, a sequence set forth in any one of SEQ ID NOS: 5 to 12.

Human anti-human influenza virus antibody

The present invention relates to a method for detecting an avian influenza virus by an immunological assay using an anti-influenza virus antibody being unreactive to human influenza type-A virus subtypes H1, H2 and H3 and a human influenza type-B virus and being reactive to plural subtypes of avian influenza viruses, and an immunochromatographic test tool for use in the method. According to the present invention, an avian influenza virus can be detected specifically, rapidly and in a simple manner, as distinguishing an avian influenza virus from a human influenza virus.

Rapid diagnosis method specific to avian influenza virus

An antibody library is prepared by selecting a light chain variable region capable of binding to the variable region of heavy chain to reproduce an active conformation and using the same. Because of being capable of maintaining the diversity of the heavy chain variable region at a high ratio in vitro, the antibody library of the present invention is expected as enabling the acquisition of antibodies with various binding activities.

Antibody library

Growing community of inventors

Osaka, Japan

Yoshinobu Okuno