Japan Science and Technology Agency

Nitta Gelatin Inc.

National Institute for Materials Science

Tabata, Yasuhiko

Yoshinobu Mandai

Junzo Tanaka

Masanori Kikuchi

Noriichi Ito

Fumihito Sugihara

Kazuo Takakuda

Hiroko Matsumoto

Kazuhiko Minamigawa

Yoshihisa Koyama

Kohji Nagatomi

Yasuhiko Tabata

This invention provides organic/inorganic composite biomaterials constituted by composites of hydroxyapatite and collagen and having an average fiber length of 60 &#x3bc;m or longer, and a process for producing the same in which the calcium ion and phosphate ion concentrations in the reaction vessel are optimized through regulation of the concentration of a starting material and the flow rate. The organic/inorganic composite biomaterials have mechanical strength and a biodegradation rate suitable for artificial bones through the introduction of crosslinking therein.

Organic/inorganic composite biomaterials and process for producing the same

This invention relates to a method for regulating the biodegradability of composite biomaterials comprising calcium salt (particularly hydroxyapatite) and collagen, improved composite biomaterials obtained via such method, and a method for increasing bone mass with the use of such composite biomaterials.

Regulation of biodegradability of composite biomaterials

A hardenable, biocompatible composition for repairing firm living tissue which includes a powder component containing Ca.sub.4 P.sub.2 O.sub.9 and at least one of CaHPO.sub.4 and CaHPO.sub.4.H.sub.2 O at a molar ratio of Ca:P of 1.16-1.95; and a liquid component containing 1 mM to 2M of a second phosphate ion and 1 mM to 2M of an organic ion. The weight ratio of the powder component to the liquid component is 0.5-4.0.

Biologically compatible hardening material for dental or medical

Growing community of inventors

Osaka, Japan

Yoshinobu Mandai