Riken Corporation

The University of Tokyo

Yoshinobu Hashizume

Yasuko Koda

Kohei Miyazono

Akiko Tanaka

Hirofumi Yamamoto

Fumihiko Ishikawa

Yoriko Saito

Hitomi Yuki

Hirokazu Kubota

Hiroo Koyama

Tomonori Taguri

Katsuhiko Sekimata

Tomohiro Sato

The present invention relates to novel and excellent small-molecule-compounds that specifically antagonize BMP signal pathways, and these compounds can be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus can be used to treat diseases or pathological symptoms related to BMP signal pathway including inflammation, cardiovascular diseases, hematopoietic diseases, cancer, osteodystrophia, or the like, particularly, fibrodysplasia ossificans progressiva, and the present invention relates to provision of a pharmaceutical and pharmacological agent used for specifically antagonizing the BMP signal pathways and acting on the BMP signal pathways in the prevention and treatment or experimental application since the compounds can be beneficial for regulating cell differentiation and/or cell proliferation.

BMP-signal-inhibiting compound

This invention relates to an agent for treating or inhibiting recurrence of acute myeloid leukemia and an agent for inhibiting growth of leukemia stem cells comprising a compound represented by formula (I) or a salt thereof: wherein Arand Areach represent aryl or heteroaryl; L represents O, S, NH, NHCO, or CONH; X represents CH or N; Y represents C-alkylene; Zrepresents hydrogen, C-alkyl, amino-C-alkyl, C-alkylamino-C-alkyl, di(C-alkyl)amino-C-alkyl, hydroxy-C-alkyl, C-alkoxy-C-alkyl, or carboxy-C-alkyl; and Zrepresents C-alkyl, amino-C-alkyl, C-alkylamino-C-alkyl, di(C-alkyl)amino-C-alkyl, hydroxy-C-alkyl, C-alkoxy-C-alkyl, or carboxy-C-alkyl, Zand Zmay, together with adjacent nitrogen, form a heterocyclic group containing as a ring member one or more hetero atoms, in addition to the nitrogen adjacent to Zand Z.

Agent for treating or inhibiting recurrence of acute myeloid leukemia

Growing community of inventors

Saitama, Japan

Yoshinobu Hashizume