Eisai R&d Management Co., Ltd.

Eisai Company, Limited

Yoshimitsu Naoe

Taro Terauchi

Fumihiro Ozaki

Itaru Tsukada

Atsushi Kamada

Nobuaki Sato

Toshiaki Tanaka

Toshihiko Kaneko

Shuhei Miyazawa

Mitsuaki Miyamoto

Tetsuya Kawahara

Richard S Clark

Kazuo Okano

Akiharu Kajiwara

Nobuhisa Watanabe

Ieharu Hishinuma

Norio Karibe

Hideyuki Adachi

Kazuki Miyazaki

Hiroshi Tanaka

Masanobu Shinoda

Fumiyoshi Matsuura

Makoto Kotake

Hiroki Ishihara

Takashi Doko

Tadashi Nagakura

Yu Yoshida

Toshiyuki Matsuoka

Shuichi Suzuki

Kohtarou Kodama

Keiichi Sorimachi

Yuji Kazuta

Akifumi Kimura

Motoji Kogushi

Osamu Ito

Hiroko Kobayashi

Naoto Ono

Ken-ichi Chiba

Yoshiaki Oohashi

Syuhei Miyazawa

Ayumi Takemura

Motohiro Soejima

Tsutomu Kawata

Huiming Zhang

Norihito Ohi

George Moniz

Jaemoon Lee

Takafumi Motoki

Farid Benayoud

Takashi Musha

Carsten T Beuckmann

Annie Zhu Wilcoxen

Tsutomu Kawada

Takashi Musya

George Anthony Moniz

Ken-Ichi Chiba

Keni-Ichi Chiba

Takashii Musha

The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.

Methods and compounds useful in the synthesis of orexin-2 receptor antagonists

A cyclopropane compound represented by the following formula (A) or a pharmaceutically acceptable salt thereof has orexin receptor antagonism, and therefore has a potencial of usefulness for the treatment of sleep disorder for which orexin receptor antagonism is effective, for example, insomnia: wherein Q represents &#x2014;CH&#x2014; or a nitrogen atom, Rand Reach independently represent a Calkyl group and the like, Rrepresents a hydrogen atom and the like, R, R, Rand Reach independently represent a hydrogen atom, a halogen atom, a Calkyl group and the like, R, Rand Reach independently represent a hydrogen atom, a halogen atom and the like, and Rrepresents a hydrogen atom and the like.

Cyclopropane compound

The present invention provides a novel compound having an excellent JNK inhibitory effect. That is, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein Rdesignates &#x2014;(CO)&#x2014;(NR)&#x2014;(CR&#x2550;CR)&#x2014;Ar (wherein R, Rand Reach independently designate a hydrogen atom, a halogen atom, hydroxyl group, an optionally substituted Calkyl group or the like;

Pyrazole compound and medicinal composition containing the same

A 2-iminoimidazole derivative represented by the formula: {wherein R, Rand Rrepresent hydrogen, optionally substituted Calkyl, etc.; Rrepresents hydrogen, Calkyl, Calkyloxycarbonyl, etc.; Yrepresents a single bond, &#x2014;CH&#x2014;, etc.; Yrepresents a single bond, &#x2014;CO&#x2014;, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R&#x2013;Rrepresent hydrogen, Calkyl, hydroxyl, Calkoxy, etc., and Rand Ror Rand Rmay bond together to form a 5- to 8-membered heterocycle], etc.}or salt thereof.

2-iminoimidazole derivatives (2)

A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R&#x2013;Rrepresent hydrogen, halogen, Calkyl, etc.; Rrepresents hydrogen, Calkyl, Calkoxy-Calkyl, etc.; Rrepresents hydrogen, Calkyl, Calkyloxycarbonyl, etc.; Yrepresents a single bond, &#x2014;CH&#x2014;, etc.; Yrepresents a single bond, &#x2014;CO&#x2014;, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R&#x2014;Rrepresent hydrogen, Calkyl, hydroxyl, Calkoxy, etc.; and Rand Ror Rand Rmay bond together to form a 5- to 8-membered heterocyclic ring], etc.},or a salt thereof.

2-iminopyrrolidine derivatives

Phthalazine compounds and therapeutic agents for erectile dysfunction

Phthalazine derivatives and remedies for erectile dysfunction

Growing community of inventors

Tsukuba, Japan

Yoshimitsu Naoe