Ishihara Sangyo Kaisha, Ltd.

Kyoto University

Yoshimichi Ueda

Takashi Nakamura

Koji Goto

Takehiro Shibuya

Tokuo Suita

Hiroaki Nishii

Nobutoshi Yamada

Masashi Imamura

Hideo Sugawa

Toru Mori

The purpose of the present invention is to provide a bone cement composition which can have desired biological activity performance and desired radiolucency while enabling the strength of a cured product thereof to be kept. A titanium oxide coating is formed on radiolucent particles to thereby produce composite particles, and the composite particles are added to a bone cement composition. The bone cement composition thus produced can be used suitably for the filling of a bone defect portion and the fixation of an artificial joint and in percutaneous vertebroplasty. The shape of each of the radiolucent particles is preferably granular, and the titanium oxide is preferably of a rutile type.

Bone cement composition

A bone cement composition which contains titanium dioxide particles having a median diameter of 0.5 to 7.0 &#x3bc;m as measured by a laser diffraction/scattering particle size distribution analyzer and a BET specific surface area of 0.5 to 7.0 m/g as measured by a nitrogen adsorption method, and a base-forming component comprising a (meth)acrylate polymer and a (meth)acrylate monomer, wherein the content of the titanium dioxide particles is 5 to 50% by mass based on the total mass of the composition. The bone cement composition has bioactivity and is capable of forming a hardened material having a high mechanical strength.

Bone cement composition and production method thereof, and kit for producing the same

A bone cement composition which contains large-diameter (meth)acrylate polymer particles having an average particle diameter of 10 to 60 &#x3bc;m, small-diameter (meth)acrylate polymer particles having an average particle diameter of 0.1 to 2.0 &#x3bc;m, a (meth)acrylate monomer and a polymerization initiator, wherein the content of the small-diameter (meth)acrylate polymer particles is 5 to 30% by mass based on the total mass of the small-diameter (meth)acrylate polymer particles and the large-diameter (meth)acrylate polymer particles, and a part or a whole of the small-diameter (meth)acrylate polymer particles are contained in the form of aggregates having an average particle diameter of 30 to 50 &#x3bc;m.

Bone cement composition, bone cement composition kit and forming method of bone cement hardened material

Peptide or its salt for autoimmune hyperthyroidism containing it

Growing community of inventors

Kusatsu, Japan

Yoshimichi Ueda